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10.1038/srep36817 http://scihub22266oqcxt.onion/10.1038/srep36817 C5108044!5108044 !27841359     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27841359 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics |pdf=|usr=}}{{27841359 }} gab.com Text Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27841359 #FOAvip Chronic kidney disease (CKD) is frequently complicated with hyponatremia, probably because of fluid overload or diuretic usage. Hyponatremia in CKD population is associated with increased mortality, but the effect on renal outcome was unknown. We investigated whether hyponatremia is associated with fluid status and is a prognostic indicator for adverse outcomes in a CKD cohort of 4,766 patients with 1,009 diuretic users. We found that diuretic users had worse clinical outcomes compared with diuretic non-users. Hyponatremia (serum sodium <135?mEq/L) was associated with excessive volume and volume depletion, measured as total body water by bioimpedance analysis, in diuretic users, but not in diuretic non-users. Furthermore, in Cox survival analysis, hyponatremia was associated with an increased risk for renal replacement therapy (hazard ratio, 1.45; 95% CI, 1.13-1.85, P?<?0.05) in diuretic users, but not in diuretic non-users (P for interaction <0.05); restricted cubic spline model also showed a similar result. Hyponatremia was not associated with all-cause mortality or cardiovascular event whereas hypernatremia (serum sodium >141?mEq/L) was associated with an increased risk for all-cause mortality. Thus, hyponatremia is an indicator of fluid imbalance and also a prognostic factor for renal replacement therapy in CKD patients treated with diuretics. Twit Text FOAVip Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27841359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27841359 #FOAvip English Wikipedia <ref>{{Cite pmid|27841359 }}</ref> Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics #MMPMID27841359 Lim LM ; Tsai NC ; Lin MY ; Hwang DY ; Lin HY ; Lee JJ ; Hwang SJ ; Hung CC ; Chen HC Sci Rep 2016[Nov]; 6 (ä): 36817 PMID27841359 show ga Chronic kidney disease (CKD) is frequently complicated with hyponatremia, probably because of fluid overload or diuretic usage. Hyponatremia in CKD population is associated with increased mortality, but the effect on renal outcome was unknown. We investigated whether hyponatremia is associated with fluid status and is a prognostic indicator for adverse outcomes in a CKD cohort of 4,766 patients with 1,009 diuretic users. We found that diuretic users had worse clinical outcomes compared with diuretic non-users. Hyponatremia (serum sodium <135?mEq/L) was associated with excessive volume and volume depletion, measured as total body water by bioimpedance analysis, in diuretic users, but not in diuretic non-users. Furthermore, in Cox survival analysis, hyponatremia was associated with an increased risk for renal replacement therapy (hazard ratio, 1.45; 95% CI, 1.13-1.85, P?141?mEq/L) was associated with an increased risk for all-cause mortality. Thus, hyponatremia is an indicator of fluid imbalance and also a prognostic factor for renal replacement therapy in CKD patients treated with diuretics. |Aged [MESH] |Cohort Studies [MESH] |Diuretics/*adverse effects [MESH] |Female [MESH] |Humans [MESH] |Hyponatremia/*etiology [MESH] |Male [MESH] |Middle Aged [MESH] |Prognosis [MESH] |Renal Insufficiency, Chronic/complications/*drug therapy [MESH] |Survival Analysis [MESH]Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outc(epmc).pdf DeepDyve Pubget Overpricing