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2016 ; 3
(4
): 253-260
Nephropedia Template TP
gab.com Text
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English Wikipedia
Characteristics of patients with haematological and breast cancer (1996-2009) who
died of heart failure-related causes after cancer therapy
#MMPMID27867526
Versace VL
; Berry NM
; Chowdhury MH
; Ullah S
; McCarthy AL
; Atherton JJ
; Koczwara B
; Roder D
; Clark RA
ESC Heart Fail
2016[Dec]; 3
(4
): 253-260
PMID27867526
show ga
AIMS: To describe the characteristics and time to death of patients with breast
or haematological cancer who died of heart failure (HF) after cancer therapy.
Patients with an index admission for HF who died of HF-related causes (IAHF) and
those with no index admission for HF who died of HF-related causes (NIAHF) were
compared. METHODS AND RESULTS: We performed a linked data analysis of cancer
registry, death registry, and hospital administration records (n?=?15?987). Index
HF admission must have occurred after cancer diagnosis. Of the 4894 patients who
were deceased (30.6% of cohort), 734 died of HF-related causes (50.1% female) of
which 279 (38.0%) had at least one IAHF (41.9% female) post-cancer diagnosis.
Median age was 71?years [interquartile range (IQR) 62-78] for IAHF and 66?years
(IQR 56-74) for NIAHF. There were fewer chemotherapy separations for IAHF
patients (median?=?4, IQR 2-9) compared with NIAHF patients (median?=?6, IQR
2-12). Of the IAHF patients, 71% had died within 1?year of the index HF
admission. There was no significant difference in HF-related mortality in IAHF
patients compared with NIAHF (HR, 1.10, 95% CI, 0.94-1.29, P?=?0.225).
CONCLUSIONS: The profile of IAHF patients who died of HF-related causes after
cancer treatment matched the current profile of HF in the general population
(over half were aged ?70?years). However, NIAHF were younger (62% were aged
?69?years), female patients with breast cancer that died of HF-related causes
before hospital admission for HF-related causes-a group that may have been
undiagnosed or undertreated until death.