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10.1038/srep36841 http://scihub22266oqcxt.onion/10.1038/srep36841 C5107926!5107926 !27841357     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27841357 &cmd=llinks): Failed to open stream: HTTP request failed! 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Emergence of human G2P 4 rotaviruses containing animal derived gene segments in the post-vaccine era |pdf=|usr=}}{{27841357 }} gab.com Text Emergence of human G2P 4 rotaviruses containing animal derived gene segments in the post-vaccine era JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27841357 #FOAvip The introduction of Rotarix into the Belgian immunization program in June 2006 coincided with an increase of the relative prevalence of G2P[4] strains. However, the genetic composition of these persistent G2P[4] strains has not been investigated. Therefore, we have investigated the NSP4 gene of 89 Belgian G2P[4] strains detected between 1999 and 2013, covering both pre- and post-vaccination periods. The NSP4 genes were divided over seven separate clusters of which six were more closely related to animal than to human strains. The NSP4 genes that clustered more closely to animal DS-1-like strains were isolated after 2004-2005 and were found throughout multiple seasons. Complete genome sequencing of 28 strains identified several other gene segments that clustered more closely to animal than to human DS-1-like strains. These findings suggest that frequent interspecies reassortments may have played a role in the spread of G2P[4] rotaviruses in the post-vaccination period in Belgium. Twit Text FOAVip Emergence of human G2P 4 rotaviruses containing animal derived gene segments in the post-vaccine era ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27841357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27841357 #FOAvip English Wikipedia <ref>{{Cite pmid|27841357 }}</ref> Emergence of human G2P 4 rotaviruses containing animal derived gene segments in the post-vaccine era #MMPMID27841357 Zeller M ; Nuyts V ; Heylen E ; De Coster S ; Conceição-Neto N ; Van Ranst M ; Matthijnssens J Sci Rep 2016[Nov]; 6 (ä): 36841 PMID27841357 show ga The introduction of Rotarix into the Belgian immunization program in June 2006 coincided with an increase of the relative prevalence of G2P[4] strains. However, the genetic composition of these persistent G2P[4] strains has not been investigated. Therefore, we have investigated the NSP4 gene of 89 Belgian G2P[4] strains detected between 1999 and 2013, covering both pre- and post-vaccination periods. The NSP4 genes were divided over seven separate clusters of which six were more closely related to animal than to human strains. The NSP4 genes that clustered more closely to animal DS-1-like strains were isolated after 2004-2005 and were found throughout multiple seasons. Complete genome sequencing of 28 strains identified several other gene segments that clustered more closely to animal than to human DS-1-like strains. These findings suggest that frequent interspecies reassortments may have played a role in the spread of G2P[4] rotaviruses in the post-vaccination period in Belgium. |Animals [MESH] |Belgium [MESH] |Evolution, Molecular [MESH] |Genome, Viral [MESH] |Glycoproteins/*genetics [MESH] |Humans [MESH] |Phylogeny [MESH] |Reassortant Viruses/*classification/genetics [MESH] |Rotavirus Vaccines [MESH] |Rotavirus/*classification/genetics [MESH] |Sequence Analysis, RNA/*methods [MESH] |Toxins, Biological/*genetics [MESH] |Vaccination [MESH] |Vaccines, Attenuated [MESH]Emergence of human G2P 4 rotaviruses containing animal derived gene s(epmc).pdf DeepDyve Pubget Overpricing