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10.1038/nrm.2016.93 http://scihub22266oqcxt.onion/10.1038/nrm.2016.93 C5107309!5107309!27552971     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27552971&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2016 ; 17 (11): 679-90 Nephropedia Template TP {{tp|p=27552971|t=2016. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds |pdf=|usr=}}{{27552971}} gab.com Text Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27552971 #FOAvip The sirtuins (SIRT1?7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans. Twit Text FOAVip Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27552971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27552971 #FOAvip English Wikipedia <ref>{{Cite pmid|27552971}}</ref> Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds #MMPMID27552971 Bonkowski MS; Sinclair DA Nat Rev Mol Cell Biol 2016[Nov]; 17 (11): 679-90 PMID27552971show ga The sirtuins (SIRT1?7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans. äSlowing ageing by design: the rise of NAD+ and sirtuin-activating comp(epmc).pdf DeepDyve Pubget Overpricing