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10.1007/s40472-016-0115-8 http://scihub22266oqcxt.onion/10.1007/s40472-016-0115-8 C5107184!5107184!27909647     free     free     free       Curr+Transplant+Rep 2016 ; 3 (4): 275-83 Nephropedia Template TP {{tp|p=27909647|t=2016. What Is Direct Allorecognition?|pdf=|usr=}}{{27909647}} gab.com Text What Is Direct Allorecognition JO: Curr Transplant Rep http://www.kidney.de/pget.php?&tw=1&pmid=27909647 #FOAvip Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived ?passenger? dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct allospecificity and how self-restricted T cells recognise allogeneic MHC-peptide complexes. These theories, both of which are supported by functional and structural data, suggest that T cells recognising allogeneic MHC-peptide complexes focus either on the allopeptides bound to the allo-MHC molecules or the allo-MHC molecules themselves. We discuss how direct alloimmune responses may be sustained long term, the consequences of this for graft outcome and highlight novel strategies which are currently being investigated as a potential means of reducing rejection mediated through this pathway. Twit Text FOAVip What Is Direct Allorecognition ????Curr Transplant Rep http://www.kidney.de/pget.php?&tw=1&pmid=27909647 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27909647 #FOAvip English Wikipedia <ref>{{Cite pmid|27909647}}</ref> What Is Direct Allorecognition? #MMPMID27909647 Boardman DA; Jacob J; Smyth LA; Lombardi G; Lechler RI Curr Transplant Rep 2016[]; 3 (4): 275-83 PMID27909647show ga Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived ?passenger? dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct allospecificity and how self-restricted T cells recognise allogeneic MHC-peptide complexes. These theories, both of which are supported by functional and structural data, suggest that T cells recognising allogeneic MHC-peptide complexes focus either on the allopeptides bound to the allo-MHC molecules or the allo-MHC molecules themselves. We discuss how direct alloimmune responses may be sustained long term, the consequences of this for graft outcome and highlight novel strategies which are currently being investigated as a potential means of reducing rejection mediated through this pathway. äWhat Is Direct Allorecognition?(epmc).pdf DeepDyve Pubget Overpricing