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10.4196/kjpp.2016.20.6.613 http://scihub22266oqcxt.onion/10.4196/kjpp.2016.20.6.613 C5106395!5106395 !27847438     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27847438 &cmd=llinks): Failed to open stream: HTTP request failed! 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Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3? signaling in rats |pdf=|usr=}}{{27847438 }} gab.com Text Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3 signaling in rats JO: Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27847438 #FOAvip Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1) to modulate DCM and its related mechanisms. Twenty-four male Wistar rats were injected with streptozotocin (STZ, 60 mg/kg) to mimic diabetes mellitus. Myocardial fibrosis and apoptosis were evaluated by histopathologic analyses, and relevant proteins were analyzed by Western blotting. Inflammatory factors were assessed by ELISA. Markers of oxidative stress were tested by colorimetric analysis. Rats with DCM displayed decreased body weight, metabolic abnormalities, elevated apoptosis (as assessed by the bcl-2/bax ratio and TUNEL assays), increased fibrosis, increased markers of oxidative stress (MDA and SOD) and inflammatory factors (TNF-? and IL-1?), and decreased phosphorylation of Akt and glycogen synthase kinase (GSK-3?). IGF-1 treatment, however, attenuated the metabolic abnormalities and myocardial apoptosis, interstitial fibrosis, oxidative stress and inflammation seen in diabetic rats, while also increasing the phosphorylation levels of Akt and GSK-3?. These findings suggest that IGF-1 ameliorates the pathophysiological progress of DCM along with an activation of the Akt/GSK-3? signaling pathway. Our findings suggest that IGF-1 could be a potential therapeutic choice for controlling DCM. Twit Text FOAVip Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3 signaling in rats ????Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27847438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27847438 #FOAvip English Wikipedia <ref>{{Cite pmid|27847438 }}</ref> Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3? signaling in rats #MMPMID27847438 Wang CY ; Li XD ; Hao ZH ; Xu D Korean J Physiol Pharmacol 2016[Nov]; 20 (6 ): 613-619 PMID27847438 show ga Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1) to modulate DCM and its related mechanisms. Twenty-four male Wistar rats were injected with streptozotocin (STZ, 60 mg/kg) to mimic diabetes mellitus. Myocardial fibrosis and apoptosis were evaluated by histopathologic analyses, and relevant proteins were analyzed by Western blotting. Inflammatory factors were assessed by ELISA. Markers of oxidative stress were tested by colorimetric analysis. Rats with DCM displayed decreased body weight, metabolic abnormalities, elevated apoptosis (as assessed by the bcl-2/bax ratio and TUNEL assays), increased fibrosis, increased markers of oxidative stress (MDA and SOD) and inflammatory factors (TNF-? and IL-1?), and decreased phosphorylation of Akt and glycogen synthase kinase (GSK-3?). IGF-1 treatment, however, attenuated the metabolic abnormalities and myocardial apoptosis, interstitial fibrosis, oxidative stress and inflammation seen in diabetic rats, while also increasing the phosphorylation levels of Akt and GSK-3?. These findings suggest that IGF-1 ameliorates the pathophysiological progress of DCM along with an activation of the Akt/GSK-3? signaling pathway. Our findings suggest that IGF-1 could be a potential therapeutic choice for controlling DCM. äInsulin-like growth factor-1 improves diabetic cardiomyopathy through (epmc).pdf DeepDyve Pubget Overpricing