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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(45
): e5329
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English Wikipedia
Application of high-resolution ultrasound, real-time elastography, and
contrast-enhanced ultrasound in differentiating solid thyroid nodules
#MMPMID27828854
Zhang YZ
; Xu T
; Gong HY
; Li CY
; Ye XH
; Lin HJ
; Shen MP
; Duan Y
; Yang T
; Wu XH
Medicine (Baltimore)
2016[Nov]; 95
(45
): e5329
PMID27828854
show ga
High-resolution ultrasound (HRUS) is a sensitive tool for identifying thyroid
nodules. Real-time elastography (RTE) and contrast-enhanced ultrasound (CEUS) are
newly developed methods which could measure tissue elasticity and perfusion
features. The aim of the present study was to evaluate and compare the diagnostic
efficiency of HRUS, RTE, CEUS and their combined use in the differentiation of
benign and malignant solid thyroid nodules.In total, 111 consecutive patients
with 145 thyroid nodules who were scheduled for surgery were included in the
study. All of them underwent HRUS, RTE, and CEUS examination. The independent
ultrasound (US) predictors for malignancy were determined and quantified using
logistic regression analysis, based on which a risk-scoring model was established
for each method. The diagnostic efficiency of each method was assessed by
receiver operating characteristic (ROC) curve analysis.HRUS showed the best
diagnostic efficiency among the 3 US methods, with 74.6% sensitivity and 87.8%
specificity. CEUS had higher sensitivity (85.7%), whereas RTE alone did not show
much advantage. Combined use of RTE and HRUS increased the sensitivity (92.1%).
The HRUS-RTE-CEUS combination could increase both the sensitivity and specificity
(87.3%, 91.5%), with the best AUC (0.935) among all the methods.The overall
diagnostic value of HRUS in predicting malignancy is the best among the 3 US
methods. Combined use of RTE and CEUS and HRUS could improve the diagnostic
efficiency for solid thyroid nodules.