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10.1177/0748730416668049 http://scihub22266oqcxt.onion/10.1177/0748730416668049 C5105327!5105327!27702781     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Rhythms 2016 ; 31 (6): 588-97 Nephropedia Template TP {{tp|p=27702781|t=2016. Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans |pdf=|usr=}}{{27702781}} gab.com Text Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans JO: J Biol Rhythms http://www.kidney.de/pget.php?&tw=1&pmid=27702781 #FOAvip The daily timing of mammalian physiology is coordinated by circadian clocks throughout the body. Although measurements of clock gene expression indicate that these clocks in mice are normally in phase with each other, the situation in humans remains unclear. We used publicly available data from five studies, comprising over 1000 samples, to compare the phasing of circadian gene expression in human brain and human blood. Surprisingly, after controlling for age, clock gene expression in brain was phase-delayed by ~8.5 h relative to that of blood. We then examined clock gene expression in two additional human organs and in organs from nine other mammalian species, as well as in the suprachiasmatic nucleus (SCN). In most tissues outside the SCN, the expression of clock gene orthologs showed a phase difference of ~12 h between diurnal and nocturnal species. The exception to this pattern was human brain, whose phasing resembled that of the SCN. Our results highlight the value of a multi-tissue, multi-species meta-analysis, and have implications for our understanding of the human circadian system. Twit Text FOAVip Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans ????J Biol Rhythms http://www.kidney.de/pget.php?&tw=1&pmid=27702781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27702781 #FOAvip English Wikipedia <ref>{{Cite pmid|27702781}}</ref> Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans #MMPMID27702781 Hughey JJ; Butte AJ J Biol Rhythms 2016[Dec]; 31 (6): 588-97 PMID27702781show ga The daily timing of mammalian physiology is coordinated by circadian clocks throughout the body. Although measurements of clock gene expression indicate that these clocks in mice are normally in phase with each other, the situation in humans remains unclear. We used publicly available data from five studies, comprising over 1000 samples, to compare the phasing of circadian gene expression in human brain and human blood. Surprisingly, after controlling for age, clock gene expression in brain was phase-delayed by ~8.5 h relative to that of blood. We then examined clock gene expression in two additional human organs and in organs from nine other mammalian species, as well as in the suprachiasmatic nucleus (SCN). In most tissues outside the SCN, the expression of clock gene orthologs showed a phase difference of ~12 h between diurnal and nocturnal species. The exception to this pattern was human brain, whose phasing resembled that of the SCN. Our results highlight the value of a multi-tissue, multi-species meta-analysis, and have implications for our understanding of the human circadian system. äDifferential Phasing between Circadian Clocks in the Brain and Periphe(epmc).pdf DeepDyve Pubget Overpricing