Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27847545
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Aesthet+Dermatol
2016 ; 9
(10
): 18-27
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Efficacy, Safety, and Dermal Tolerability of Dapsone Gel, 7 5% in Patients with
Moderate Acne Vulgaris: A Pooled Analysis of Two Phase 3 Trials
#MMPMID27847545
Thiboutot DM
; Kircik L
; McMichael A
; Cook-Bolden FE
; Tyring SK
; Berk DR
; Chang-Lin JE
; Lin V
; Kaoukhov A
J Clin Aesthet Dermatol
2016[Oct]; 9
(10
): 18-27
PMID27847545
show ga
Objective: Assess efficacy and safety of once-daily topical dapsone gel, 7.5%
compared with vehicle for treating acne vulgaris (acne). Design: A pooled
analysis of data from two identically designed, randomized, double-blind,
vehicle-controlled, multicenter, 12-week clinical trials. Setting: Study sites in
the United States and Canada. Participants: overall, 4,340 patients were
randomized 1:1 to dapsone and vehicle. Criteria included age 12 years or older
with acne diagnosis, 20 to 50 facial inflammatory lesions (papules and pustules),
30 to 100 facial noninflammatory lesions (open and closed comedones), and acne
grade of 3 (moderate) on the Global Acne Assessment Score scale. Measurements:
Efficacy assessments included the Global Acne Assessment Score success rate
(proportion of patients with Global Acne Assessment Score of 0 [none] or 1
[minimal]) and percentage change from baseline in inflammatory and
noninflammatory lesions at Week 12. Results: Global Acne Assessment Score success
rates were 29.8 percent and 21.1 percent for patients who received dapsone gel,
7.5% and vehicle, respectively (p<0.001). Patients receiving dapsone gel, 7.5%
had greater percentage change in lesion counts than patients receiving vehicle
(inflammatory lesions: -54.6% vs. -48.1%; p<0.001; -45.1 %; noninflammatory
lesions: -39.4%; p<0.001). Most adverse events were mild to moderate in severity.
Mean dermal tolerability scores for stinging/burning, dryness, scaling, and
erythema were similarly low with dapsone gel, 7.5% and vehicle. Conclusion:
Dapsone gel, 7.5%, with a 50-percent greater dapsone concentration than
twice-daily dapsone gel, 5% formulation, is applied topically once daily for
acne, is effective, safe, and well-tolerated over 12 weeks, and has local
tolerability similar to that of vehicle. www.clinicaltrials.gov identifiers:
NCT01974141 and NCT01974323.