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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Scleroderma+Relat+Disord
2016 ; 1
(2
): 226-233
Nephropedia Template TP
gab.com Text
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English Wikipedia
A Randomized Controlled Trial of Acupressure for the Treatment of Raynaud s
Phenomenon: The difficulty of conducting a trial in Raynaud s phenomenon
#MMPMID27840853
Gladue H
; Berrocal V
; Harris R
; Tsou PS
; Edhayan G
; Ohara R
; Khanna D
J Scleroderma Relat Disord
2016[May]; 1
(2
): 226-233
PMID27840853
show ga
OBJECTIVE: To examine the effect of acupressure on Raynaud's phenomenon (RP) in a
randomized controlled clinical trial (RCT) and to evaluate the difficulties of
conducting a RP RCT. METHODS: A pilot single center RCT of acupressure vs.
targeted patient education was conducted for the treatment of RP. Patients with
either primary (N = 15) or secondary (N = 8) RP were randomized in an 8-week
study. The primary endpoints included a decrease in the frequency and duration of
RP. Secondary endpoints included several serum biomarkers including endothelial
dysfunction, Raynaud's attack symptoms, Raynaud's Condition Score, and patient
and physician global assessments of RP. Primary data analysis was conducted using
the last observation carried forward and t-tests or a Wilcoxon rank test was used
to compare the two groups. RESULTS: 23 patients were randomized and 7
discontinued prematurely. 78% of patients were female, 96% were Caucasian, and
the mean age was 49.8 (SD=16) years. No statistically significant differences
were detected between the acupressure vs. education groups in primary and
secondary outcomes (p> 0.05). Frequency of attacks decreased by 6.7 attacks
(SD=8.8) in the acupressure group vs. 7.2 (SD=12.8) in the education group
(p=0.96), and the duration of attacks decreased by 11.4 (SD=19.9) minutes in the
acupressure group vs. an increase of 0.8 minutes (SD=11.2) in the education group
(p=0.14). There were no adverse events noted in the RCT. CONCLUSION: This pilot
study does not support efficacy of acupressure for RP.