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2016 ; 12
(5
): 3472-3474
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Conversion of aspergilloma to chronic necrotizing pulmonary aspergillosis
following treatment with sunitinib: A case report
#MMPMID27900022
Kim YW
; Lee HW
; Cho J
; Choi HS
; Lee J
; Park SS
; Heo EY
; Jin KN
; Kim DK
Oncol Lett
2016[Nov]; 12
(5
): 3472-3474
PMID27900022
show ga
Semi-invasive or invasive aspergillosis occurring following chemotherapy with
sunitinib is a rare condition with unknown incidence and prognosis. Here, we
report a case involving a 59-year-old male who had a history of underlying stable
aspergilloma and was newly diagnosed with metastatic renal cell carcinoma.
Following surgical resection for renal cell carcinoma and adjuvant chemotherapy
with sunitinib for 8 months, the patient presented with hemoptysis. Chest
computed tomography revealed an increased soft tissue mass and air crescent sign
of the underlying aspergilloma, combined with consolidation and bronchial artery
hypertrophy around the lesion. The patient underwent bronchoscopy with a biopsy
of the lesion and was eventually diagnosed with chronic necrotizing pulmonary
aspergillosis, which had progressed from the underlying stable aspergilloma. This
case highlights the fact that clinicians should be aware of the risk of
opportunistic conversion from stable aspergilloma to invasive fungal infections
in patients undergoing sunitinib treatment.