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10.3892/ol.2016.5124 http://scihub22266oqcxt.onion/10.3892/ol.2016.5124 C5103903!5103903 !27899964     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27899964 &cmd=llinks): Failed to open stream: HTTP request failed! 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Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance |pdf=|usr=}}{{27899964 }} gab.com Text Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=27899964 #FOAvip Radioresistance remains a major obstacle for the radiotherapy treatment of cancer. Previous studies have demonstrated that the radioresistance of cancer is due to the existence of intrinsic cancer stem cells (CSCs), which represent a small, but radioresistant cell subpopulation that exist in heterogeneous tumors. By contrast, non-stem cancer cells are considered to be radiosensitive and thus, easy to kill. However, recent studies have revealed that under conditions of radiation-induced stress, theoretically radiosensitive non-stem cancer cells may undergo dedifferentiation subsequently obtaining the phenotypes and functions of CSCs, including high resistance to radiotherapy, which indicates that radiation may directly result in the generation of novel CSCs from non-stem cancer cells. These findings suggest that in addition to intrinsic CSCs, non-stem cancer cells may also contribute to the relapse and metastasis of cancer following transformation into CSCs. This review aims to investigate the radiation-induced generation of CSCs, its association with epithelial-mesenchymal transition and its significance with regard to the radioresistance of cancer. Twit Text FOAVip Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=27899964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27899964 #FOAvip English Wikipedia <ref>{{Cite pmid|27899964 }}</ref> Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance #MMPMID27899964 Li F ; Zhou K ; Gao L ; Zhang B ; Li W ; Yan W ; Song X ; Yu H ; Wang S ; Yu N ; Jiang Q Oncol Lett 2016[Nov]; 12 (5 ): 3059-3065 PMID27899964 show ga Radioresistance remains a major obstacle for the radiotherapy treatment of cancer. Previous studies have demonstrated that the radioresistance of cancer is due to the existence of intrinsic cancer stem cells (CSCs), which represent a small, but radioresistant cell subpopulation that exist in heterogeneous tumors. By contrast, non-stem cancer cells are considered to be radiosensitive and thus, easy to kill. However, recent studies have revealed that under conditions of radiation-induced stress, theoretically radiosensitive non-stem cancer cells may undergo dedifferentiation subsequently obtaining the phenotypes and functions of CSCs, including high resistance to radiotherapy, which indicates that radiation may directly result in the generation of novel CSCs from non-stem cancer cells. These findings suggest that in addition to intrinsic CSCs, non-stem cancer cells may also contribute to the relapse and metastasis of cancer following transformation into CSCs. This review aims to investigate the radiation-induced generation of CSCs, its association with epithelial-mesenchymal transition and its significance with regard to the radioresistance of cancer. äRadiation induces the generation of cancer stem cells: A novel mechani(epmc).pdf DeepDyve Pubget Overpricing