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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mol+Clin+Oncol
2016 ; 5
(5
): 545-549
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Small-cell lung cancer with recurrent syncope as the initial symptom: A case
report and literature review
#MMPMID27900081
Jiang X
; Zhao J
; Bai C
; Xu E
; Chen Z
; Han Y
Mol Clin Oncol
2016[Nov]; 5
(5
): 545-549
PMID27900081
show ga
Small-cell lung cancer (SCLC) presenting with syncope as the initial symptom is
rare in adults. This onset of tumour-induced syncope cannot be screened or
differentiated by coronary angiography, magnetic resonance angiography of the
neck or 24-hour dynamic electrocardiogram. We herein describe the case of a
61-year-old man who presented with recurrent syncope that resolved after the
first course of chemotherapy (carboplatin plus etoposide) for SCLC. A mass
measuring 57×53 mm was identified in the left hilum, and a diagnosis of
limited-disease SCLC (T4N2M0, IIIB) was made. Considering the rapid and complete
remission after the treatment of the primary lesion, we hypothesised that the
syncope was neurogenic and associated with cancer. Thus, 8 similar cases
retrieved from PubMed were reviewed and, for the first time, the mechanism
underlying the syncope was identified, which may involve tumour location,
neurobiology and other inducing factors. Thus, for the treatment of such SCLC
patients, standard chemotherapy is crucial for preventing syncopal attacks.