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10.3892/etm.2016.3782 http://scihub22266oqcxt.onion/10.3892/etm.2016.3782 C5103839!5103839!27882179     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Ther+Med 2016 ; 12 (5): 3459-63 Nephropedia Template TP {{tp|p=27882179|t=2016. Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis |pdf=|usr=}}{{27882179}} gab.com Text Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27882179 #FOAvip Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis. The hypoxia-inducible transcription factor HIF-1? and VEGF signaling has a critical role in regulating osteoclastic bone-resorption and angiogenesis, and increased osteoclastogenesis and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis. The cells of the osteoblast lineage also have important roles in angiogenic-osteogenic coupling. The research in this field might help limiting the disability associated with the disease. Twit Text FOAVip Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27882179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27882179 #FOAvip English Wikipedia <ref>{{Cite pmid|27882179}}</ref> Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis #MMPMID27882179 Siao-Pin S; Damian LO; Muntean LM; Rednic S Exp Ther Med 2016[Nov]; 12 (5): 3459-63 PMID27882179show ga Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis. The hypoxia-inducible transcription factor HIF-1? and VEGF signaling has a critical role in regulating osteoclastic bone-resorption and angiogenesis, and increased osteoclastogenesis and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis. The cells of the osteoblast lineage also have important roles in angiogenic-osteogenic coupling. The research in this field might help limiting the disability associated with the disease. äAcroosteolysis in systemic sclerosis: An insight into hypoxia-related (epmc).pdf DeepDyve Pubget Overpricing