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2016 ; 7
(6
): 471-485
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gab.com Text
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English Wikipedia
Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of
parents and their offspring in a rodent model
#MMPMID27624382
Javurek AB
; Spollen WG
; Johnson SA
; Bivens NJ
; Bromert KH
; Givan SA
; Rosenfeld CS
Gut Microbes
2016[Nov]; 7
(6
): 471-485
PMID27624382
show ga
Gut dysbiosis may result in various diseases, such as metabolic and
neurobehavioral disorders. Exposure to endocrine disrupting chemicals (EDCs),
including bisphenol A (BPA) and ethinyl estradiol (EE), especially during
development, may also increase the risk for such disorders. An unexplored
possibility is that EDC-exposure might alter the gut microbial composition. Gut
flora and their products may thus be mediating factors for the disease-causing
effects of these chemicals. To examine the effects of EDCs on the gut microbiome,
female and male monogamous and biparental California mice (Peromyscus
californicus) were exposed to BPA (50 mg/kg feed weight) or EE (0.1 ppb) or
control diet from periconception through weaning. 16s rRNA sequencing was
performed on bacterial DNA isolated from fecal samples, and analyses performed
for P(0) and F(1) males and females. Both BPA and EE induced generational and
sex-dependent gut microbiome changes. Many of the bacteria, e.g. Bacteroides,
Mollicutes, Prevotellaceae, Erysipelotrichaceae, Akkermansia, Methanobrevibacter,
Sutterella, whose proportions increase with exposure to BPA or EE in the P(0) or
F(1) generation are associated with different disorders, such as inflammatory
bowel disease (IBD), metabolic disorders, and colorectal cancer. However, the
proportion of the beneficial bacterium, Bifidobacterium, was also elevated in
fecal samples of BPA- and EE-exposed F(1) females. Intestinal flora alterations
were also linked to changes in various metabolic and other pathways. Thus, BPA
and EE exposure may disrupt the normal gut flora, which may in turn result in
systemic effects. Probiotic supplementation might be an effective means to
mitigate disease-promoting effects of these chemicals.