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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2016 ; 17
(1
): 170
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Intracystic magnetic resonance imaging in patients with autosomal dominant
polycystic kidney disease: features of severe cyst infection in a case-control
study
#MMPMID27829402
Suwabe T
; Ubara Y
; Ueno T
; Hayami N
; Hoshino J
; Imafuku A
; Kawada M
; Hiramatsu R
; Hasegawa E
; Sawa N
; Saitoh S
; Okuda I
; Takaichi K
BMC Nephrol
2016[Nov]; 17
(1
): 170
PMID27829402
show ga
BACKGROUND: The purpose of this study was to investigate the usefulness of
intracystic MRI features for detection of severe cyst infection that is usually
refractory to antibiotic therapy alone in patients with autosomal dominant
polycystic kidney disease. METHODS: Seventy-six patients (88 episodes) with
positive cyst cultures treated from January 2006 to December 2013 were enrolled
as the cases for this case-control study, while 147 patients who continued to
attend our hospital from January 2011 to December 2013 and did not have cyst
infection diagnosed during that period were enrolled as the controls. Intracystic
MRI findings were investigated. RESULTS: At least one of four intracystic MRI
features (high signal intensity (SI) on diffusion-weighted images (DWI),
fluid-fluid level, wall thickening, or gas) was found in all of the cases, but
such findings were also detected in some controls. Intracystic gas was specific
for cyst infection, but its sensitivity was only 1.1 %. A high intracystic SI on
DWI showed a sensitivity of 86.4 %, but its specificity was lower at 33.3 %. Both
the specificity and sensitivity of a fluid-fluid level or wall thickening were
about 80 %. However, the specificity of these MRI features decreased as total
liver and kidney volume (TLKV) increased, falling to 65.8 % in patients with
organomegaly (TLKV?>?8500 cm(3)). A cyst diameter?>?5 cm was useful for detecting
severely infected cysts that needed drainage, and specificity was increased by
combining the other four MRI findings with a cyst diameter?>?5 cm. CONCLUSIONS:
MRI with DWI was useful for detecting severe cyst infection in ADPKD. While the
specificity of MRI alone was not high enough in patients with organomegaly,
combining the four MRI features with abdominal pain, sequential MRI changes, or
cyst diameter?>?5 cm improved detection of severely infected cysts in these
patients.
|Adult
[MESH]
|Aged
[MESH]
|Bacterial Infections/*diagnostic imaging
[MESH]
|Case-Control Studies
[MESH]
|Cysts/*diagnostic imaging/microbiology
[MESH]
|Diffusion Magnetic Resonance Imaging/*methods
[MESH]
free
free
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