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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pak+J+Med+Sci 2016 ; 32 (5): 1131-4 Nephropedia Template TP
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Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus #MMPMID27882008
Hai A; Kizilbash N
Pak J Med Sci 2016[Sep]; 32 (5): 1131-4 PMID27882008show ga
Objective:: The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes. Methods:: Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na+, K+-ATPase. Results:: The results show that Porphyrin compounds exert an insulin-like effect on Na+, K+-ATPase. They act by increasing the activity of the membrane-bound enzyme. Conclusion:: All the three Porphyrin compounds increased the activity of erythrocyte Na+, K+-ATPase. The exact mechanism of action of these compounds is not clear.