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10.12669/pjms.325.11530

http://scihub22266oqcxt.onion/10.12669/pjms.325.11530
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C5103120!5103120 !27882008
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suck abstract from ncbi


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pmid27882008
      Pak+J+Med+Sci 2016 ; 32 (5 ): 1131-1134
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  • Increase in activity of Na(+), K(+)-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus #MMPMID27882008
  • Hai A ; Kizilbash N
  • Pak J Med Sci 2016[Sep]; 32 (5 ): 1131-1134 PMID27882008 show ga
  • OBJECTIVE: The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes. METHODS: Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na(+), K(+)-ATPase. RESULTS: The results show that Porphyrin compounds exert an insulin-like effect on Na(+), K(+)-ATPase. They act by increasing the activity of the membrane-bound enzyme. CONCLUSION: All the three Porphyrin compounds increased the activity of erythrocyte Na(+), K(+)-ATPase. The exact mechanism of action of these compounds is not clear.
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