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2016 ; 32
(5
): 1131-1134
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Increase in activity of Na(+), K(+)-ATPase by Porphyrin compounds as treatment
for Dysnatremias caused by Diabetes Mellitus
#MMPMID27882008
Hai A
; Kizilbash N
Pak J Med Sci
2016[Sep]; 32
(5
): 1131-1134
PMID27882008
show ga
OBJECTIVE: The aim of this study was to test the action of Porphyrin compounds,
Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl)
porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis
(4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+,
K+ -ATPase of cell membrane of erythrocytes. METHODS: Enzymatic assays, measuring
the amount of inorganic phosphate produced, were used to estimate the activity of
Na(+), K(+)-ATPase. RESULTS: The results show that Porphyrin compounds exert an
insulin-like effect on Na(+), K(+)-ATPase. They act by increasing the activity of
the membrane-bound enzyme. CONCLUSION: All the three Porphyrin compounds
increased the activity of erythrocyte Na(+), K(+)-ATPase. The exact mechanism of
action of these compounds is not clear.