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10.1016/j.bpj.2016.09.021 http://scihub22266oqcxt.onion/10.1016/j.bpj.2016.09.021 C5103008!5103008 !27806280     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27806280 &cmd=llinks): Failed to open stream: HTTP request failed! 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Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature |pdf=|usr=}}{{27806280 }} gab.com Text Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27806280 #FOAvip Gangliosides are a class of glycosphingolipids (GSLs) with amphiphilic character that are found at the outer leaflet of the cell membranes, where their ability to organize into special domains makes them vital cell membrane components. However, a molecular understanding of GSL-rich membranes in terms of their clustered organization, stability, and dynamics is still elusive. To gain molecular insight into the organization and dynamics of GSL-rich membranes, we performed all-atom molecular-dynamics simulations of bicomponent ganglioside GM1 in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipid bilayers with varying concentrations of GM1 (10%, 20%, and 30%). Overall, the simulations show very good agreement with available experimental data, including x-ray electron density profiles along the membrane normal, NMR carbohydrate proton-proton distances, and x-ray crystal structures. This validates the quality of our model systems for investigating GM1 clustering through an ordered-lipid-cluster analysis. The increase in GM1 concentration induces tighter lipid packing, driven mainly by inter-GM1 carbohydrate-carbohydrate interactions, leading to a greater preference for the positive curvature of GM1-containing membranes and larger cluster sizes of ordered-lipid clusters (with a composite of GM1 and POPC). These clusters tend to segregate and form a large percolated cluster at a 30% GM1 concentration at 293 K. At a higher temperature of 330 K, however, the segregation is not maintained. Twit Text FOAVip Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27806280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27806280 #FOAvip English Wikipedia <ref>{{Cite pmid|27806280 }}</ref> Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature #MMPMID27806280 Patel DS ; Park S ; Wu EL ; Yeom MS ; Widmalm G ; Klauda JB ; Im W Biophys J 2016[Nov]; 111 (9 ): 1987-1999 PMID27806280 show ga Gangliosides are a class of glycosphingolipids (GSLs) with amphiphilic character that are found at the outer leaflet of the cell membranes, where their ability to organize into special domains makes them vital cell membrane components. However, a molecular understanding of GSL-rich membranes in terms of their clustered organization, stability, and dynamics is still elusive. To gain molecular insight into the organization and dynamics of GSL-rich membranes, we performed all-atom molecular-dynamics simulations of bicomponent ganglioside GM1 in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipid bilayers with varying concentrations of GM1 (10%, 20%, and 30%). Overall, the simulations show very good agreement with available experimental data, including x-ray electron density profiles along the membrane normal, NMR carbohydrate proton-proton distances, and x-ray crystal structures. This validates the quality of our model systems for investigating GM1 clustering through an ordered-lipid-cluster analysis. The increase in GM1 concentration induces tighter lipid packing, driven mainly by inter-GM1 carbohydrate-carbohydrate interactions, leading to a greater preference for the positive curvature of GM1-containing membranes and larger cluster sizes of ordered-lipid clusters (with a composite of GM1 and POPC). These clusters tend to segregate and form a large percolated cluster at a 30% GM1 concentration at 293 K. At a higher temperature of 330 K, however, the segregation is not maintained. |Carbohydrate Conformation [MESH] |Cell Membrane/chemistry/*drug effects/metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |G(M1) Ganglioside/*pharmacology [MESH] |Hydrogen Bonding [MESH] |Hydrophobic and Hydrophilic Interactions [MESH] |Lipid Bilayers/chemistry/metabolism [MESH] |Membrane Lipids/*chemistry/*metabolism [MESH] |Molecular Dynamics Simulation [MESH] |Oligosaccharides/chemistry/metabolism [MESH]Influence of Ganglioside GM1 Concentration on Lipid Clustering and Mem(epmc).pdf DeepDyve Pubget Overpricing