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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mol+Biol+Rep
2016 ; 43
(12
): 1321-1326
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Use of Fourier-transform infrared spectroscopy in the diagnosis of rheumatoid
arthritis: a pilot study
#MMPMID27640014
Lechowicz L
; Chrapek M
; Gaweda J
; Urbaniak M
; Konieczna I
Mol Biol Rep
2016[Dec]; 43
(12
): 1321-1326
PMID27640014
show ga
Rheumatoid arthritis is an autoimmune inflammatory disease leading to joint
cartilage, bone degradation and limitation of mobility. Diagnosis of RA is
difficult and complex. There are also no effective methods for clear
discrimination between RA patients and non-RA individuals. In this work we use IR
spectroscopy to differentiate RA patients and blood donors' sera. We found
differences between investigated sera (RA and non-RA) in range of 3000-2800 and
1800-800 cm(-1) (W1-W5 regions). Based on mathematical analysis we developed a
K-NN model characterized by 85?% of sensitivity and 100?% of specificity. Also we
found that, wavenumber 1424 cm(-1), comprising in W3 region, was the most
effective in human sera distinguishing. We conclude that IR spectroscopy may
serve as a fast and easy method useful in RA serology.