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2016 ; 17
(6
): 940-949
Nephropedia Template TP
gab.com Text
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English Wikipedia
Clinical Features and Radiological Findings of Adenovirus Pneumonia Associated
with Progression to Acute Respiratory Distress Syndrome: A Single Center Study in
19 Adult Patients
#MMPMID27833410
Cha MJ
; Chung MJ
; Lee KS
; Kim TJ
; Kim TS
; Chong S
; Han J
Korean J Radiol
2016[Nov]; 17
(6
): 940-949
PMID27833410
show ga
OBJECTIVE: To describe radiologic findings of adenovirus pneumonia and to
understand clinico-radiological features associated with progression to acute
respiratory distress syndrome (ARDS) in patients with adenovirus pneumonia.
MATERIALS AND METHODS: This study included 19 patients diagnosed with adenovirus
pneumonia at a tertiary referral center, in the period between March 2003 and
April 2015. Clinical findings were reviewed, and two radiologists assessed
imaging findings by consensus. Chi-square, Fisher's exact, and Student's t tests
were used for comparing patients with and without subsequent development of ARDS.
RESULTS: Of 19 patients, nine were immunocompromised, and 10 were
immunocompetent. Twelve patients (63%) progressed to ARDS, six of whom (32%)
eventually died from the disease. The average time for progression to ARDS from
symptom onset was 9.6 days. Initial chest radiographic findings were normal (n =
2), focal opacity (n = 9), or multifocal or diffuse opacity (n = 8). Computed
tomography (CT) findings included bilateral (n = 17) or unilateral (n = 2)
ground-glass opacity with consolidation (n = 14) or pleural effusion (n = 11).
Patients having subsequent ARDS had a higher probability of pleural effusion and
a higher total CT extent compared with the non-ARDS group (p = 0.010 and 0.007,
respectively). However, there were no significant differences in clinical
variables such as patient age and premorbid condition. CONCLUSION: Adenovirus
pneumonia demonstrates high rates of ARDS and mortality, regardless of patient
age and premorbid conditions, in the tertiary care setting. Large disease extent
and presence of pleural effusion on CT are factors suggestive of progression to
ARDS.