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2016 ; 7
(ä): 193
Nephropedia Template TP
gab.com Text
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English Wikipedia
Deep Brain Stimulation for Tourette s Syndrome: The Case for Targeting the
Thalamic Centromedian-Parafascicular Complex
#MMPMID27891112
Testini P
; Min HK
; Bashir A
; Lee KH
Front Neurol
2016[]; 7
(ä): 193
PMID27891112
show ga
Tourette's syndrome (TS) is a neurologic condition characterized by both motor
and phonic tics and is typically associated with psychiatric comorbidities,
including obsessive-compulsive disorder/behavior and attention-deficit
hyperactivity disorder, and can be psychologically and socially debilitating. It
is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as
suggested by pathophysiology studies and therapeutic options. Among these, deep
brain stimulation (DBS) of the centromedian-parafascicular nucleus (CM-Pf) of the
thalamus is emerging as a valuable treatment modality for patients affected by
severe, treatment-resistant TS. Here, we review the most recent experimental
evidence for the pivotal role of CM-Pf in the pathophysiology of TS, discuss
potential mechanisms of action that may mediate the effects of CM-Pf DBS in TS,
and summarize its clinical efficacy.