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10.3389/fneur.2016.00193

http://scihub22266oqcxt.onion/10.3389/fneur.2016.00193
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suck abstract from ncbi


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pmid27891112
      Front+Neurol 2016 ; 7 (ä): 193
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  • Deep Brain Stimulation for Tourette s Syndrome: The Case for Targeting the Thalamic Centromedian-Parafascicular Complex #MMPMID27891112
  • Testini P ; Min HK ; Bashir A ; Lee KH
  • Front Neurol 2016[]; 7 (ä): 193 PMID27891112 show ga
  • Tourette's syndrome (TS) is a neurologic condition characterized by both motor and phonic tics and is typically associated with psychiatric comorbidities, including obsessive-compulsive disorder/behavior and attention-deficit hyperactivity disorder, and can be psychologically and socially debilitating. It is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as suggested by pathophysiology studies and therapeutic options. Among these, deep brain stimulation (DBS) of the centromedian-parafascicular nucleus (CM-Pf) of the thalamus is emerging as a valuable treatment modality for patients affected by severe, treatment-resistant TS. Here, we review the most recent experimental evidence for the pivotal role of CM-Pf in the pathophysiology of TS, discuss potential mechanisms of action that may mediate the effects of CM-Pf DBS in TS, and summarize its clinical efficacy.
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