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10.1155/2016/1719720 http://scihub22266oqcxt.onion/10.1155/2016/1719720 C5102736!5102736 !27868072     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27868072 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol+Res 2016 ; 2016 (ä): 1719720 Nephropedia Template TP {{tp|p=27868072 |t=2016. The Role of TLR4 on B Cell Activation and Anti-?(2)GPI Antibody Production in the Antiphospholipid Syndrome |pdf=|usr=}}{{27868072 }} gab.com Text The Role of TLR4 on B Cell Activation and Anti- (2)GPI Antibody Production in the Antiphospholipid Syndrome JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27868072 #FOAvip High titer of anti-?(2)-glycoprotein I antibodies (anti-?(2)GPI Ab) plays a pathogenic role in antiphospholipid syndrome (APS). Numerous studies have focused on the pathological mechanism in APS; however, little attention is paid to the immune mechanism of production of anti-?(2)GPI antibodies in APS. Our previous study demonstrated that Toll-like receptor 4 (TLR4) plays a vital role in the maturation of bone marrow-derived dendritic cells (BMDCs) from the mice immunized with human ?(2)-glycoprotein I (?(2)GPI). TLR4 is required for the activation of B cells and the production of autoantibody in mice treated with ?(2)GPI. However, TLR4 provides a third signal for B cell activation and then promotes B cells better receiving signals from both B cell antigen receptor (BCR) and CD40, thus promoting B cell activation, surface molecules expression, anti-?(2)GPI Ab production, and cytokines secretion and making B cell functioning like an antigen presenting cell (APC). At the same time, TLR4 also promotes B cells producing antibodies by upregulating the expression of B-cell activating factor (BAFF). In this paper, we aim to review the functions of TLR4 in B cell immune response and antibody production in autoimmune disease APS and try to find a new way for the prevention and treatment of APS. Twit Text FOAVip The Role of TLR4 on B Cell Activation and Anti- (2)GPI Antibody Production in the Antiphospholipid Syndrome ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27868072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27868072 #FOAvip English Wikipedia <ref>{{Cite pmid|27868072 }}</ref> The Role of TLR4 on B Cell Activation and Anti-?(2)GPI Antibody Production in the Antiphospholipid Syndrome #MMPMID27868072 Cheng S ; Wang H ; Zhou H J Immunol Res 2016[]; 2016 (ä): 1719720 PMID27868072 show ga High titer of anti-?(2)-glycoprotein I antibodies (anti-?(2)GPI Ab) plays a pathogenic role in antiphospholipid syndrome (APS). Numerous studies have focused on the pathological mechanism in APS; however, little attention is paid to the immune mechanism of production of anti-?(2)GPI antibodies in APS. Our previous study demonstrated that Toll-like receptor 4 (TLR4) plays a vital role in the maturation of bone marrow-derived dendritic cells (BMDCs) from the mice immunized with human ?(2)-glycoprotein I (?(2)GPI). TLR4 is required for the activation of B cells and the production of autoantibody in mice treated with ?(2)GPI. However, TLR4 provides a third signal for B cell activation and then promotes B cells better receiving signals from both B cell antigen receptor (BCR) and CD40, thus promoting B cell activation, surface molecules expression, anti-?(2)GPI Ab production, and cytokines secretion and making B cell functioning like an antigen presenting cell (APC). At the same time, TLR4 also promotes B cells producing antibodies by upregulating the expression of B-cell activating factor (BAFF). In this paper, we aim to review the functions of TLR4 in B cell immune response and antibody production in autoimmune disease APS and try to find a new way for the prevention and treatment of APS. |Animals [MESH] |Antibodies, Antiphospholipid/biosynthesis/*immunology [MESH] |Antibody Formation/*immunology [MESH] |Antiphospholipid Syndrome/*immunology/*metabolism/therapy [MESH] |Autoantigens/immunology [MESH] |Autoimmunity [MESH] |B-Cell Activating Factor/metabolism [MESH] |B-Lymphocytes/*immunology/*metabolism [MESH] |Cell Differentiation/immunology [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Immunotherapy [MESH] |Lymphocyte Activation/*immunology [MESH] |Molecular Targeted Therapy [MESH] |Signal Transduction [MESH] |T-Lymphocytes/immunology/metabolism [MESH] |Toll-Like Receptor 4/*metabolism [MESH]The Role of TLR4 on B Cell Activation and Anti-?(2)GPI Antibody Produc(epmc).pdf DeepDyve Pubget Overpricing