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10.3332/ecancer.2016.680 http://scihub22266oqcxt.onion/10.3332/ecancer.2016.680 C5102691!5102691!27899953     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ecancermedicalscience 2016 ; 10 (ä): ä Nephropedia Template TP {{tp|p=27899953|t=2016. Repurposing Drugs in Oncology (ReDO)?Propranolol as an anti-cancer agent |pdf=|usr=}}{{27899953}} gab.com Text Repurposing Drugs in Oncology (ReDO) Propranolol as an anti-cancer agent JO: Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=27899953 #FOAvip Propranolol (PRO) is a well-known and widely used non-selective beta-adrenergic receptor antagonist (beta-blocker), with a range of actions which are of interest in an oncological context. PRO displays effects on cellular proliferation and invasion, on the immune system, on the angiogenic cascade, and on tumour cell sensitivity to existing treatments. Both pre-clinical and clinical evidence of these effects, in multiple cancer types, is assessed and summarised and relevant mechanisms of action outlined. In particular there is evidence that PRO is effective at multiple points in the metastatic cascade, particularly in the context of the post-surgical wound response. Based on this evidence the case is made for further clinical investigation of the anticancer effects of PRO, particularly in combination with other agents. A number of trials are on-going, in different treatment settings for various cancers. Twit Text FOAVip Repurposing Drugs in Oncology (ReDO) Propranolol as an anti-cancer agent ????Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=27899953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27899953 #FOAvip English Wikipedia <ref>{{Cite pmid|27899953}}</ref> Repurposing Drugs in Oncology (ReDO)?Propranolol as an anti-cancer agent #MMPMID27899953 Pantziarka P; Bouche G; Sukhatme V; Meheus L; Rooman I; Sukhatme VP Ecancermedicalscience 2016[]; 10 (ä): ä PMID27899953show ga Propranolol (PRO) is a well-known and widely used non-selective beta-adrenergic receptor antagonist (beta-blocker), with a range of actions which are of interest in an oncological context. PRO displays effects on cellular proliferation and invasion, on the immune system, on the angiogenic cascade, and on tumour cell sensitivity to existing treatments. Both pre-clinical and clinical evidence of these effects, in multiple cancer types, is assessed and summarised and relevant mechanisms of action outlined. In particular there is evidence that PRO is effective at multiple points in the metastatic cascade, particularly in the context of the post-surgical wound response. Based on this evidence the case is made for further clinical investigation of the anticancer effects of PRO, particularly in combination with other agents. A number of trials are on-going, in different treatment settings for various cancers. äRepurposing Drugs in Oncology (ReDO)?Propranolol as an anti-cancer age(epmc).pdf DeepDyve Pubget Overpricing