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10.1002/eji.201546253 http://scihub22266oqcxt.onion/10.1002/eji.201546253 C5102679!5102679!26806881     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26806881&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26806881.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2016 ; 46 (4): 857-62 Nephropedia Template TP {{tp|p=26806881|t=2016. Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors |pdf=|usr=}}{{26806881}} gab.com Text Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26806881 #FOAvip Thymic epithelial cells (TECs) provide essential signals for ??T?cell development, and medullary TECs (mTECs) control T?cell tolerance through both negative selection and Foxp3+ regulatory T (Treg) cell development. Although heterogeneity within the mTEC compartment is well studied, the molecular regulators of specific stages of mTEC development are still poorly understood. Given the importance of the RANK?RANKL axis in thymus medulla formation, we have used RANK Venus reporter mice to analyze the ontogeny of RANK+ TECs during development and correlated RANK expression with mTEC stem cells defined by SSEA?1. In addition, we have investigated how requirements for the key regulators Foxn1 and Relb map to specific stages of mTEC development. Here, we show SSEA?1+ mTEC stem cells emerge prior to RANK expression and are present in both nude and Relb?/? mice, providing direct evidence that mTEC lineage specification occurs independently of Foxn1 and Relb. In contrast, we show that Relb is necessary for the effective production of downstream RANK+ mTEC progenitors. Collectively, our work defines stage?specific requirements for critical TEC regulators during medulla development, including the timing of Relb dependency, and provides new information on mechanisms controlling mTEC specification. Twit Text FOAVip Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26806881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26806881 #FOAvip English Wikipedia <ref>{{Cite pmid|26806881}}</ref> Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors #MMPMID26806881 Baik S; Sekai M; Hamazaki Y; Jenkinson WE; Anderson G Eur J Immunol 2016[Apr]; 46 (4): 857-62 PMID26806881show ga Thymic epithelial cells (TECs) provide essential signals for ??T?cell development, and medullary TECs (mTECs) control T?cell tolerance through both negative selection and Foxp3+ regulatory T (Treg) cell development. Although heterogeneity within the mTEC compartment is well studied, the molecular regulators of specific stages of mTEC development are still poorly understood. Given the importance of the RANK?RANKL axis in thymus medulla formation, we have used RANK Venus reporter mice to analyze the ontogeny of RANK+ TECs during development and correlated RANK expression with mTEC stem cells defined by SSEA?1. In addition, we have investigated how requirements for the key regulators Foxn1 and Relb map to specific stages of mTEC development. Here, we show SSEA?1+ mTEC stem cells emerge prior to RANK expression and are present in both nude and Relb?/? mice, providing direct evidence that mTEC lineage specification occurs independently of Foxn1 and Relb. In contrast, we show that Relb is necessary for the effective production of downstream RANK+ mTEC progenitors. Collectively, our work defines stage?specific requirements for critical TEC regulators during medulla development, including the timing of Relb dependency, and provides new information on mechanisms controlling mTEC specification. äRelb acts downstream of medullary thymic epithelial stem cells and is (epmc).pdf DeepDyve Pubget Overpricing