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10.1002/eji.201545599 http://scihub22266oqcxt.onion/10.1002/eji.201545599 C5102633!5102633!26036683     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2015 ; 45 (8): 2409-19 Nephropedia Template TP {{tp|p=26036683|t=2015. Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus |pdf=|usr=}}{{26036683}} gab.com Text Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26036683 #FOAvip The principles of allelic exclusion state that each B cell expresses a single light and heavy chain pair. Here, we show that B cells with both kappa and lambda light chains (Ig? and Ig?) are enriched in some patients with the systemic autoimmune disease systemic lupus erythematosus (SLE), but not in the systemic autoimmune disease control granulomatosis with polyangiitis. Detection of dual Ig? and Ig? expression by flow cytometry could not be abolished by acid washing or by DNAse treatment to remove any bound polyclonal antibody or complexes, and was retained after two days in culture. Both surface and intracytoplasmic dual light chain expression was evident by flow cytometry and confocal microscopy. We observed reduced frequency of rearrangements of the kappa?deleting element (KDE) in SLE and an inverse correlation between the frequency of KDE rearrangement and the frequency of dual light chain expressing B cells. We propose that dual expression of Ig? and Ig? by a single B cell may occur in some patients with SLE when this may be a consequence of reduced activity of the KDE. Twit Text FOAVip Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26036683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26036683 #FOAvip English Wikipedia <ref>{{Cite pmid|26036683}}</ref> Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus #MMPMID26036683 Fraser LD; Zhao Y; Lutalo PMK; D'Cruz DP; Cason J; Silva JS; Dunn?Walters DK; Nayar S; Cope AP; Spencer J Eur J Immunol 2015[Aug]; 45 (8): 2409-19 PMID26036683show ga The principles of allelic exclusion state that each B cell expresses a single light and heavy chain pair. Here, we show that B cells with both kappa and lambda light chains (Ig? and Ig?) are enriched in some patients with the systemic autoimmune disease systemic lupus erythematosus (SLE), but not in the systemic autoimmune disease control granulomatosis with polyangiitis. Detection of dual Ig? and Ig? expression by flow cytometry could not be abolished by acid washing or by DNAse treatment to remove any bound polyclonal antibody or complexes, and was retained after two days in culture. Both surface and intracytoplasmic dual light chain expression was evident by flow cytometry and confocal microscopy. We observed reduced frequency of rearrangements of the kappa?deleting element (KDE) in SLE and an inverse correlation between the frequency of KDE rearrangement and the frequency of dual light chain expressing B cells. We propose that dual expression of Ig? and Ig? by a single B cell may occur in some patients with SLE when this may be a consequence of reduced activity of the KDE. äImmunoglobulin light chain allelic inclusion in systemic lupus erythem(epmc).pdf DeepDyve Pubget Overpricing