Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/mmr.2016.5818 http://scihub22266oqcxt.onion/10.3892/mmr.2016.5818 C5101998!5101998 !27748879     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27748879 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2016 ; 14 (5 ): 4559-4566 Nephropedia Template TP {{tp|p=27748879 |t=2016. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis |pdf=|usr=}}{{27748879 }} gab.com Text Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27748879 #FOAvip Constitutive photomorphogenesis 9 signalosome (CSN) consists of a total of eight subunits (CSN1-CSN8) in mammalian cells. CSN6 may promote carcinogenesis by positively regulating v?myc avian myelocytomatosis viral oncogene homolog (Myc) and MDM2 proto?oncogene stability, and is regarded as a potential target for cancer therapy. Quercetin has a substantial anticancer effect on various human cancer cells. The present study investigated the effects of quercetin on HT-29 human colorectal cancer cell viability, apoptosis and cell cycle arrest using an MTT assay, flow cytometry, transmission electron microscopy and western blotting. It was determined that quercetin inhibited HT?29 cell viability in a dose?dependent manner. Cell shrinkage, chromatin condensation and nuclear collapse were observed in the 50, 100 and 200 µM quercetin groups. The exposure of HT?29 cells to quercetin led to significant cell cycle arrest in the S?phase. Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B?cell lymphoma 2 (Bcl?2) and Bcl?2 associated X protein. The overexpression of CSN6 reduced the effect of quercetin treatment on HT?29 cells, suggesting that quercetin?induced apoptosis may involve the Akt?CSN6?Myc signaling axis in HT?29 cells. Twit Text FOAVip Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27748879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27748879 #FOAvip English Wikipedia <ref>{{Cite pmid|27748879 }}</ref> Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis #MMPMID27748879 Yang L ; Liu Y ; Wang M ; Qian Y ; Dong X ; Gu H ; Wang H ; Guo S ; Hisamitsu T Mol Med Rep 2016[Nov]; 14 (5 ): 4559-4566 PMID27748879 show ga Constitutive photomorphogenesis 9 signalosome (CSN) consists of a total of eight subunits (CSN1-CSN8) in mammalian cells. CSN6 may promote carcinogenesis by positively regulating v?myc avian myelocytomatosis viral oncogene homolog (Myc) and MDM2 proto?oncogene stability, and is regarded as a potential target for cancer therapy. Quercetin has a substantial anticancer effect on various human cancer cells. The present study investigated the effects of quercetin on HT-29 human colorectal cancer cell viability, apoptosis and cell cycle arrest using an MTT assay, flow cytometry, transmission electron microscopy and western blotting. It was determined that quercetin inhibited HT?29 cell viability in a dose?dependent manner. Cell shrinkage, chromatin condensation and nuclear collapse were observed in the 50, 100 and 200 µM quercetin groups. The exposure of HT?29 cells to quercetin led to significant cell cycle arrest in the S?phase. Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B?cell lymphoma 2 (Bcl?2) and Bcl?2 associated X protein. The overexpression of CSN6 reduced the effect of quercetin treatment on HT?29 cells, suggesting that quercetin?induced apoptosis may involve the Akt?CSN6?Myc signaling axis in HT?29 cells. |Adaptor Proteins, Signal Transducing/*biosynthesis/genetics [MESH] |Apoptosis/drug effects [MESH] |COP9 Signalosome Complex [MESH] |Carcinogenesis/drug effects/genetics [MESH] |Cell Proliferation/drug effects [MESH] |Colonic Neoplasms/*drug therapy/genetics/pathology [MESH] |Dose-Response Relationship, Drug [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |HT29 Cells [MESH] |Humans [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/*biosynthesis/genetics [MESH] |Proto-Oncogene Proteins c-myc/*biosynthesis/genetics [MESH] |Quercetin/*administration & dosage [MESH]Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition(epmc).pdf DeepDyve Pubget Overpricing