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10.1038/cmi.2015.73 http://scihub22266oqcxt.onion/10.1038/cmi.2015.73 C5101447!5101447!26277894     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26277894&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2016 ; 13 (6): 862-70 Nephropedia Template TP {{tp|p=26277894|t=2016. Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression |pdf=|usr=}}{{26277894}} gab.com Text Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26277894 #FOAvip Lactoferrin (LF) and retinoic acid (RA) are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan (transforming growth factor-beta receptor III, T?RIII) and activation of canonical TGF-? signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line ? (GL?) transcription and GL? promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced T?RIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 (CCR9) and ?4?7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9+IgA+ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses. Twit Text FOAVip Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26277894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26277894 #FOAvip English Wikipedia <ref>{{Cite pmid|26277894}}</ref> Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression #MMPMID26277894 Lee JM; Jang YS; Jin BR; Kim SJ; Kim HJ; Kwon BE; Ko HJ; Yoon Si; Lee GS; Kim WS; Seo GY; Kim PH Cell Mol Immunol 2016[Nov]; 13 (6): 862-70 PMID26277894show ga Lactoferrin (LF) and retinoic acid (RA) are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan (transforming growth factor-beta receptor III, T?RIII) and activation of canonical TGF-? signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line ? (GL?) transcription and GL? promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced T?RIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 (CCR9) and ?4?7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9+IgA+ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses. äRetinoic acid enhances lactoferrin-induced IgA responses by increasing(epmc).pdf DeepDyve Pubget Overpricing