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10.1038/cmi.2015.72 http://scihub22266oqcxt.onion/10.1038/cmi.2015.72 C5101446!5101446!26166768     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2016 ; 13 (6): 785-94 Nephropedia Template TP {{tp|p=26166768|t=2016. Transcription factor IRF8 controls Th1-like regulatory T-cell function |pdf=|usr=}}{{26166768}} gab.com Text Transcription factor IRF8 controls Th1-like regulatory T-cell function JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26166768 #FOAvip Recent studies have suggested that regulatory T (Treg) cells comprise a heterogeneous population that regulates various aspects of the immune response, and that Treg cells use the factors that are expressed in their target cells to regulate them. We searched for factors that regulate Th1 response in Treg cells using a meta-analysis. In the process, we discovered that transcription factor interferon regulatory factor 8 (IRF8) was selectively expressed in Treg and Th1 cells. IRF8-deficient Treg cells showed defective expression of CXCR3 and aberrant expression of the Il4 and Il17 genes. Upon treatment with alpha galactosyl-C18-ceramide (?Gal-C18-Cer), IRF8-deficient mice showed defective Treg cell recruitment in the liver. Eliciting Th1 immune response by anti-CD40 antibody injection in mice induced IRF8 expression in Treg cells. The expression of IRF8 was induced by Foxp3 in Treg cells. IRF8 had no effect on T-bet expression in Treg and vice versa. Thus, our results strongly suggest that IRF8 controls Th1 immune response in Treg cells independent of T-bet. Twit Text FOAVip Transcription factor IRF8 controls Th1-like regulatory T-cell function ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26166768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26166768 #FOAvip English Wikipedia <ref>{{Cite pmid|26166768}}</ref> Transcription factor IRF8 controls Th1-like regulatory T-cell function #MMPMID26166768 Lee W; Kim HS; Baek SY; Lee GR Cell Mol Immunol 2016[Nov]; 13 (6): 785-94 PMID26166768show ga Recent studies have suggested that regulatory T (Treg) cells comprise a heterogeneous population that regulates various aspects of the immune response, and that Treg cells use the factors that are expressed in their target cells to regulate them. We searched for factors that regulate Th1 response in Treg cells using a meta-analysis. In the process, we discovered that transcription factor interferon regulatory factor 8 (IRF8) was selectively expressed in Treg and Th1 cells. IRF8-deficient Treg cells showed defective expression of CXCR3 and aberrant expression of the Il4 and Il17 genes. Upon treatment with alpha galactosyl-C18-ceramide (?Gal-C18-Cer), IRF8-deficient mice showed defective Treg cell recruitment in the liver. Eliciting Th1 immune response by anti-CD40 antibody injection in mice induced IRF8 expression in Treg cells. The expression of IRF8 was induced by Foxp3 in Treg cells. IRF8 had no effect on T-bet expression in Treg and vice versa. Thus, our results strongly suggest that IRF8 controls Th1 immune response in Treg cells independent of T-bet. äTranscription factor IRF8 controls Th1-like regulatory T-cell function(epmc).pdf DeepDyve Pubget Overpricing