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2016 ; 6
(5
): e39226
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Effect of Desmopressin on the Amount of Bleeding in Patients Undergoing
Coronary Artery Bypass Graft Surgery with a Cardiopulmonary Bypass Pump After
Taking Anti-Platelet Medicine
#MMPMID27847701
Mirmansoori A
; Farzi F
; Sedighinejad A
; Imantalab V
; Mohammadzadeh A
; Atrkar Roushan Z
; Ghazanfar Tehran S
; Nemati M
; Dehghan A
Anesth Pain Med
2016[Oct]; 6
(5
): e39226
PMID27847701
show ga
BACKGROUND: Coronary artery bypass grafting (CABG) is a common surgical
intervention at the end-stages of coronary artery occlusion disease. Despite the
effectiveness of CABG, it may have particular complications, such as bleeding
during and after surgery. So far, there have been many drugs used to reduce
bleeding. OBJECTIVES: This study aimed at investigating the effects of
desmopressin on the amount of bleeding in patients undergoing CABG with a
cardiopulmonary bypass pump (CPBP) who were taking anti-platelet medicine.
METHODS: One hundred patients scheduled for elective CABG with a CPBP were
included in a prospective, placebo-controlled, double-blinded clinical trial
study. They were randomly divided into two groups. One group received
desmopressin (40 ?g) and the other group received a placebo (isotonic saline).
Seven patients were excluded from the study, and 47 and 46 patients participated
in the desmopressin and control groups, respectively. The methods of monitoring
and the anesthetic techniques were similar in both groups, and all surgeries were
performed by one surgeon. Variables including age, gender, pump time, aortic
clamp time, duration of surgery, complications (e.g., nausea and vomiting, blood
pressure changes), the necessity to receive blood products, and coagulation tests
(prothrombin time, partial thromboplastin time, international normalized ratio,
and bleeding time) were assessed. Data were statistically analyzed with SPSS
software version 17. RESULTS: There was no significant difference between the
groups regarding age, gender, pump time, clamp time, duration of surgery,
complications, and the changes in hemoglobin and coagulation test measurements (P
> 0.05). No significant difference was noted between the groups regarding the
rate of bleeding after surgery (359.3 ± 266.2 in group D vs. 406.3 ± 341.6 in
group P (control group); P = 0.208). However, the platelet changes after surgery
in both groups were significantly different. The analysis revealed that the rate
of thrombocytopenia after surgery was higher in the control group (P = 0.012).
CONCLUSIONS: Our study showed that desmopressin could not reduce the amount of
blood loss after CABG. Also, desmopressin did not have a significant effect on
coagulation status. Therefore, based on the results of our study, it seems that
the use of this medication cannot be a helpful for patients with any indication
for CABG.
free
free
free
