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10.1016/j.cell.2016.10.005 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.10.005 C5101189!5101189!27881301     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 167 (4): 1028-1040.e15 Nephropedia Template TP {{tp|p=27881301|t=2016. Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores |pdf=|usr=}}{{27881301}} gab.com Text Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27881301 #FOAvip Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. MIS12C, on the other hand, connects the KMN to the chromosome-proximal domain of the kinetochore through a direct interaction with CENP-C. The structural basis for this crucial bridging function of MIS12C is unknown. Here, we report crystal structures of human MIS12C associated with a fragment of CENP-C and unveil the role of Aurora B kinase in the regulation of this interaction. The structure of MIS12:CENP-C complements previously determined high-resolution structures of functional regions of NDC80C and KNL1C and allows us to build a near-complete structural model of the KMN assembly. Our work illuminates the structural organization of essential chromosome segregation machinery that is conserved in most eukaryotes. Twit Text FOAVip Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27881301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27881301 #FOAvip English Wikipedia <ref>{{Cite pmid|27881301}}</ref> Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores #MMPMID27881301 Petrovic A; Keller J; Liu Y; Overlack K; John J; Dimitrova Y; Jenni S; van Gerwen S; Stege P; Wohlgemuth S; Rombaut P; Herzog F; Harrison S; Vetter I; Musacchio A Cell 2016[Nov]; 167 (4): 1028-1040.e15 PMID27881301show ga Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. MIS12C, on the other hand, connects the KMN to the chromosome-proximal domain of the kinetochore through a direct interaction with CENP-C. The structural basis for this crucial bridging function of MIS12C is unknown. Here, we report crystal structures of human MIS12C associated with a fragment of CENP-C and unveil the role of Aurora B kinase in the regulation of this interaction. The structure of MIS12:CENP-C complements previously determined high-resolution structures of functional regions of NDC80C and KNL1C and allows us to build a near-complete structural model of the KMN assembly. Our work illuminates the structural organization of essential chromosome segregation machinery that is conserved in most eukaryotes. äStructure of the MIS12 Complex and Molecular Basis of Its Interaction (epmc).pdf DeepDyve Pubget Overpricing