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2016 ; 6
(4
): e37822
Nephropedia Template TP
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The Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of
Patients With Hepatic Disease: A Review Article
#MMPMID27843779
Soleimanpour M
; Imani F
; Safari S
; Sanaie S
; Soleimanpour H
; Ameli H
; Alavian SM
Anesth Pain Med
2016[Aug]; 6
(4
): e37822
PMID27843779
show ga
CONTEXT: Patients with hepatic dysfunction suffer from many problems and
associated complications in organs other than the liver. Therefore, it is very
important to investigate the effects of different drugs in the treatment of these
patients. Due to the high consumption of non-steroidal anti-inflammatory drugs
(NSAIDs), studying the effects of these drugs in patients with hepatic
dysfunction is particularly important. EVIDENCE ACQUISITION: Research studies
published from 1958 to 2014 were investigated in the present study. The
literature search was conducted based on the following keywords: non-steroidal
anti-inflammatory drugs (NSAIDs), liver dysfunction, cirrhosis, pharmaceutical
complications, drug-induced liver injury (DILI), and similar words from reliable
resources. In total, 63 articles and two books (out of 179 initially identified
resources) were included in the study. RESULTS: In addition to significant
hemostatic disorders and cardiovascular disorders, disorders of the renal,
respiratory, and gastrointestinal systems, as well as disorders of the central
nervous system, occur in patients with hepatic dysfunction. The various NSAIDs
have different effects on different bodily systems. Therefore, the appropriate
drug should be chosen based on both the condition of the disease and the severity
of the dysfunction. CONCLUSIONS: Due to the potential adverse effects of NSAIDs
in patients with hepatic disease, their impact on all bodily systems should be
emphasized when determining whether their use is necessary. Further, the
appropriate medication should be selected after a careful assessment of the
severity of the disease and any associated complications. It is logical that
medicines should only be prescribed by a qualified physician.