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10.1093/ije/dyw046

http://scihub22266oqcxt.onion/10.1093/ije/dyw046
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C5100607!5100607!27118561
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suck abstract from ncbi


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pmid27118561      Int+J+Epidemiol 2016 ; 45 (5): 1319-28
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  • Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks #MMPMID27118561
  • Fearnley LG; Inouye M
  • Int J Epidemiol 2016[Oct]; 45 (5): 1319-28 PMID27118561show ga
  • Metabolomics is becoming feasible for population-scale studies of human disease. In this review, we survey epidemiological studies that leverage metabolomics and multi-omics to gain insight into disease mechanisms. We outline key practical, technological and analytical limitations while also highlighting recent successes in integrating these data. The use of multi-omics to infer reaction rates is discussed as a potential future direction for metabolomics research, as a means of identifying biomarkers as well as inferring causality. Furthermore, we highlight established analysis approaches as well as simulation-based methods currently used in single- and multi-cell levels in systems biology.
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