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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Epidemiol 2016 ; 45 (5): 1319-28 Nephropedia Template TP
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Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks #MMPMID27118561
Fearnley LG; Inouye M
Int J Epidemiol 2016[Oct]; 45 (5): 1319-28 PMID27118561show ga
Metabolomics is becoming feasible for population-scale studies of human disease. In this review, we survey epidemiological studies that leverage metabolomics and multi-omics to gain insight into disease mechanisms. We outline key practical, technological and analytical limitations while also highlighting recent successes in integrating these data. The use of multi-omics to infer reaction rates is discussed as a potential future direction for metabolomics research, as a means of identifying biomarkers as well as inferring causality. Furthermore, we highlight established analysis approaches as well as simulation-based methods currently used in single- and multi-cell levels in systems biology.