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10.1093/nar/gkw584 http://scihub22266oqcxt.onion/10.1093/nar/gkw584 C5100586!5100586 !27369378     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27369378 &cmd=llinks): Failed to open stream: HTTP request failed! 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Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis |pdf=|usr=}}{{27369378 }} gab.com Text Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27369378 #FOAvip Neisseria meningitidis causes bacterial meningitis and septicemia. It evades the host complement system by upregulating expression of immune evasion factors in response to changes in temperature. RNA thermometers within mRNAs control expression of bacterial immune evasion factors, including CssA, in the 5'-untranslated region of the operon for capsule biosynthesis. We dissect the molecular mechanisms of thermoregulation and report the structure of the CssA thermometer. We show that the RNA thermometer acts as a rheostat, whose stability is optimized to respond in a small temperature range around 37°C as occur within the upper airways during infection. Small increases in temperature gradually open up the structure to allow progressively increased access to the ribosome binding site. Even small changes in stability induced by mutations of imperfect base pairs, as in naturally occurring polymorphisms, shift the thermometer response outside of the desired temperature range, suggesting that its activity could be modulated by pharmacological intervention. Twit Text FOAVip Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27369378 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27369378 #FOAvip English Wikipedia <ref>{{Cite pmid|27369378 }}</ref> Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis #MMPMID27369378 Barnwal RP ; Loh E ; Godin KS ; Yip J ; Lavender H ; Tang CM ; Varani G Nucleic Acids Res 2016[Nov]; 44 (19 ): 9426-9437 PMID27369378 show ga Neisseria meningitidis causes bacterial meningitis and septicemia. It evades the host complement system by upregulating expression of immune evasion factors in response to changes in temperature. RNA thermometers within mRNAs control expression of bacterial immune evasion factors, including CssA, in the 5'-untranslated region of the operon for capsule biosynthesis. We dissect the molecular mechanisms of thermoregulation and report the structure of the CssA thermometer. We show that the RNA thermometer acts as a rheostat, whose stability is optimized to respond in a small temperature range around 37°C as occur within the upper airways during infection. Small increases in temperature gradually open up the structure to allow progressively increased access to the ribosome binding site. Even small changes in stability induced by mutations of imperfect base pairs, as in naturally occurring polymorphisms, shift the thermometer response outside of the desired temperature range, suggesting that its activity could be modulated by pharmacological intervention. |*Gene Expression Regulation, Bacterial [MESH] |*Temperature [MESH] |5' Untranslated Regions [MESH] |Bacterial Capsules/genetics/immunology [MESH] |Immune Evasion/*genetics [MESH] |Magnetic Resonance Spectroscopy [MESH] |Meningitis, Meningococcal/*immunology/*microbiology [MESH] |Models, Biological [MESH] |Mutation [MESH] |Neisseria meningitidis/*physiology [MESH] |Nucleic Acid Conformation [MESH] |Polymorphism, Genetic [MESH] |RNA Stability [MESH] |RNA, Bacterial/chemistry/*genetics [MESH]Structure and mechanism of a molecular rheostat, an RNA thermometer th(epmc).pdf DeepDyve Pubget Overpricing