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10.1083/jcb.201603080 http://scihub22266oqcxt.onion/10.1083/jcb.201603080 C5100289!5100289 !27799367     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27799367 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2016 ; 215 (3 ): 383-399 Nephropedia Template TP {{tp|p=27799367 |t=2016. Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse |pdf=|usr=}}{{27799367 }} gab.com Text Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27799367 #FOAvip Actin assembly and inward flow in the plane of the immunological synapse (IS) drives the centralization of T cell receptor microclusters (TCR MCs) and the integrin leukocyte functional antigen 1 (LFA-1). Using structured-illumination microscopy (SIM), we show that actin arcs populating the medial, lamella-like region of the IS arise from linear actin filaments generated by one or more formins present at the IS distal edge. After traversing the outer, Arp2/3-generated, lamellipodia-like region of the IS, these linear filaments are organized by myosin II into antiparallel concentric arcs. Three-dimensional SIM shows that active LFA-1 often aligns with arcs, whereas TCR MCs commonly reside between arcs, and total internal reflection fluorescence SIM shows TCR MCs being swept inward by arcs. Consistently, disrupting actin arc formation via formin inhibition results in less centralized TCR MCs, missegregated integrin clusters, decreased T-B cell adhesion, and diminished TCR signaling. Together, our results define the origin, organization, and functional significance of a major actomyosin contractile structure at the IS that directly propels TCR MC transport. Twit Text FOAVip Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27799367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27799367 #FOAvip English Wikipedia <ref>{{Cite pmid|27799367 }}</ref> Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse #MMPMID27799367 Murugesan S ; Hong J ; Yi J ; Li D ; Beach JR ; Shao L ; Meinhardt J ; Madison G ; Wu X ; Betzig E ; Hammer JA J Cell Biol 2016[Nov]; 215 (3 ): 383-399 PMID27799367 show ga Actin assembly and inward flow in the plane of the immunological synapse (IS) drives the centralization of T cell receptor microclusters (TCR MCs) and the integrin leukocyte functional antigen 1 (LFA-1). Using structured-illumination microscopy (SIM), we show that actin arcs populating the medial, lamella-like region of the IS arise from linear actin filaments generated by one or more formins present at the IS distal edge. After traversing the outer, Arp2/3-generated, lamellipodia-like region of the IS, these linear filaments are organized by myosin II into antiparallel concentric arcs. Three-dimensional SIM shows that active LFA-1 often aligns with arcs, whereas TCR MCs commonly reside between arcs, and total internal reflection fluorescence SIM shows TCR MCs being swept inward by arcs. Consistently, disrupting actin arc formation via formin inhibition results in less centralized TCR MCs, missegregated integrin clusters, decreased T-B cell adhesion, and diminished TCR signaling. Together, our results define the origin, organization, and functional significance of a major actomyosin contractile structure at the IS that directly propels TCR MC transport. |*Cell Movement [MESH] |Actin Cytoskeleton/metabolism [MESH] |Actin-Related Protein 2-3 Complex/metabolism [MESH] |Actins/metabolism [MESH] |Actomyosin/*metabolism [MESH] |Animals [MESH] |Antigen-Presenting Cells/metabolism [MESH] |CD8-Positive T-Lymphocytes/metabolism [MESH] |Cell Aggregation [MESH] |Fetal Proteins [MESH] |Fluorescence [MESH] |Formins [MESH] |Humans [MESH] |Immunological Synapses/*metabolism [MESH] |Jurkat Cells [MESH] |Lymphocyte Function-Associated Antigen-1/metabolism [MESH] |Mice [MESH] |Microfilament Proteins [MESH] |Microscopy [MESH] |Myosin Type II/metabolism [MESH] |Nuclear Proteins [MESH] |Receptors, Antigen, T-Cell/*metabolism [MESH]Formin-generated actomyosin arcs propel T cell receptor microcluster m(epmc).pdf DeepDyve Pubget Overpricing