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10.1038/srep36075 http://scihub22266oqcxt.onion/10.1038/srep36075 C5099925!5099925 !27824055     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27824055 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 36075 Nephropedia Template TP {{tp|p=27824055 |t=2016. Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-?1 pathway |pdf=|usr=}}{{27824055 }} gab.com Text Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF- 1 pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip External mechanical loading on a wound commonly increases fibrosis. Transforming growth factor-?1 (TGF-?1) has been implicated in fibrosis in various models, including the mechanical force model. However, the underlying mechanism is unclear. Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-?1 expression, and negatively impact on collagen synthesis. Our current results showed that external mechanical stretching significantly increased COL1A1, TGF-?1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. eIF6 -deficient (eIF6(+/-)) cells exhibited significantly higher levels of COL1A1, and these levels increased further with external mechanical stretching, suggesting that mechanical stretching plays a synergistic role in promoting COL1A1 expression in eIF6(+/-) cells. Inhibition of TGF?R I/II by LY2109761 decreased COL1A1 protein expression in eIF6(+/-) dermal fibroblasts in a cell stretching model, and attenuated granulation tissue formation in partial thickness wounds of eIF6(+/-) mice. These data suggest that mechanical stretching has a synergistic role in the expression of COL1A1 in eIF6(+/-) cells, and is mediated by activation of TGF?RI/II. Taken together, our results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-?1 pathway. Twit Text FOAVip Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF- 1 pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27824055 #FOAvip English Wikipedia <ref>{{Cite pmid|27824055 }}</ref> Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-?1 pathway #MMPMID27824055 Shu Q ; Tan J ; Ulrike VD ; Zhang X ; Yang J ; Yang S ; Hu X ; He W ; Luo G ; Wu J Sci Rep 2016[Nov]; 6 (ä): 36075 PMID27824055 show ga External mechanical loading on a wound commonly increases fibrosis. Transforming growth factor-?1 (TGF-?1) has been implicated in fibrosis in various models, including the mechanical force model. However, the underlying mechanism is unclear. Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-?1 expression, and negatively impact on collagen synthesis. Our current results showed that external mechanical stretching significantly increased COL1A1, TGF-?1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. eIF6 -deficient (eIF6(+/-)) cells exhibited significantly higher levels of COL1A1, and these levels increased further with external mechanical stretching, suggesting that mechanical stretching plays a synergistic role in promoting COL1A1 expression in eIF6(+/-) cells. Inhibition of TGF?R I/II by LY2109761 decreased COL1A1 protein expression in eIF6(+/-) dermal fibroblasts in a cell stretching model, and attenuated granulation tissue formation in partial thickness wounds of eIF6(+/-) mice. These data suggest that mechanical stretching has a synergistic role in the expression of COL1A1 in eIF6(+/-) cells, and is mediated by activation of TGF?RI/II. Taken together, our results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-?1 pathway. |*Stress, Mechanical [MESH] |*Stress, Physiological [MESH] |Animals [MESH] |Cell Proliferation [MESH] |Fibroblasts/*physiology [MESH] |Mice [MESH] |Peptide Initiation Factors/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH]Involvement of eIF6 in external mechanical stretch-mediated murine der(epmc).pdf DeepDyve Pubget Overpricing