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2016 ; 5
(6
): 547-550
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Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis
after sofosbuvir therapy
#MMPMID27872837
Gadde S
; Lee B
; Kidd L
; Zhang R
World J Nephrol
2016[Nov]; 5
(6
): 547-550
PMID27872837
show ga
Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with
several types of vasculitis, including pauci-immune crescentic
glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA
vasculitis has also been reported after administration of propylthiouracil,
hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine
and few other drugs. All previously reported cases of drug-associated ANCA
glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug
for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and
RPGN following sofosbuvir administration in a kidney transplant recipient. It
also represents the first case of drug-associated ANCA vasculitis in a
transplanted kidney. Further drug monitoring is necessary to elucidate the degree
of association and possible causal effect of sofosbuvir and perinuclear ANCA
vasculitis.