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10.1038/emm.2016.111 http://scihub22266oqcxt.onion/10.1038/emm.2016.111 C5099421!5099421!27741224     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2016 ; 48 (10): e265- Nephropedia Template TP {{tp|p=27741224|t=2016. Genome editing: the road of CRISPR/Cas9 from bench to clinic |pdf=|usr=}}{{27741224}} gab.com Text Genome editing: the road of CRISPR/Cas9 from bench to clinic JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27741224 #FOAvip Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings of disease states and facilitate novel therapeutic applications. Several platforms for molecular scissors that enable targeted genome engineering have been developed, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and, most recently, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated-9 (Cas9). The CRISPR/Cas9 system's simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/Cas9 has been used to generate disease models to study genetic diseases. Improvements are urgently needed for various aspects of the CRISPR/Cas9 system, including the system's precision, delivery and control over the outcome of the repair process. Here, we discuss the current status of genome engineering and its implications for the future of biological research and gene therapy. Twit Text FOAVip Genome editing: the road of CRISPR/Cas9 from bench to clinic ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27741224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27741224 #FOAvip English Wikipedia <ref>{{Cite pmid|27741224}}</ref> Genome editing: the road of CRISPR/Cas9 from bench to clinic #MMPMID27741224 Eid A; Mahfouz MM Exp Mol Med 2016[Oct]; 48 (10): e265- PMID27741224show ga Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings of disease states and facilitate novel therapeutic applications. Several platforms for molecular scissors that enable targeted genome engineering have been developed, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and, most recently, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated-9 (Cas9). The CRISPR/Cas9 system's simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/Cas9 has been used to generate disease models to study genetic diseases. Improvements are urgently needed for various aspects of the CRISPR/Cas9 system, including the system's precision, delivery and control over the outcome of the repair process. Here, we discuss the current status of genome engineering and its implications for the future of biological research and gene therapy. äGenome editing: the road of CRISPR/Cas9 from bench to clinic (epmc).pdf DeepDyve Pubget Overpricing