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10.1007/s11255-016-1420-y http://scihub22266oqcxt.onion/10.1007/s11255-016-1420-y C5099367!5099367 !27671905     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27671905 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease |pdf=|usr=}}{{27671905 }} gab.com Text Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease JO: Int Urol Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip BACKGROUND: The proteasome system is involved in several disorders. The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) -8 C/G, associated with diabetes, myocardial infarction and coronary artery disease. METHODS: We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for -8 C/G SNP by polymerase chain reaction and restriction analysis. RESULTS: We observed lower frequency of CG + GG genotypes in patients than in controls (20 vs. 42 %, p = 0.0038). The odds ratio of 0.34 (95 % CI 0.26-0.45) suggests association of CG + GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54 % of patients. There was a significant association of CG + GG genotype with LVH, with over 75 % of CG + GG in patients with LVH. This effect was independent from other common causes of LVH-age (OR 1.12, p = 0.643) and hypertension (OR 1.72, p = 0.422). CONCLUSION: We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG + GG genotypes are independently related to LVH in ESKD patients. Twit Text FOAVip Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease ????Int Urol Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27671905 #FOAvip English Wikipedia <ref>{{Cite pmid|27671905 }}</ref> Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease #MMPMID27671905 Buraczynska M ; Stec A ; Filipczak A ; Ksiazek A Int Urol Nephrol 2016[Dec]; 48 (12 ): 2083-2087 PMID27671905 show ga BACKGROUND: The proteasome system is involved in several disorders. The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) -8 C/G, associated with diabetes, myocardial infarction and coronary artery disease. METHODS: We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for -8 C/G SNP by polymerase chain reaction and restriction analysis. RESULTS: We observed lower frequency of CG + GG genotypes in patients than in controls (20 vs. 42 %, p = 0.0038). The odds ratio of 0.34 (95 % CI 0.26-0.45) suggests association of CG + GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54 % of patients. There was a significant association of CG + GG genotype with LVH, with over 75 % of CG + GG in patients with LVH. This effect was independent from other common causes of LVH-age (OR 1.12, p = 0.643) and hypertension (OR 1.72, p = 0.422). CONCLUSION: We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG + GG genotypes are independently related to LVH in ESKD patients. |Adult [MESH] |Aged [MESH] |Female [MESH] |Gene Frequency [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Hypertension/genetics [MESH] |Hypertrophy, Left Ventricular/genetics [MESH] |Kidney Failure, Chronic/*genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Poland [MESH] |Polymorphism, Single Nucleotide [MESH] |Proteasome Endopeptidase Complex/*genetics [MESH]Association between functional variant of inflammatory system gene (PS(epmc).pdf DeepDyve Pubget Overpricing