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10.1136/annrheumdis-2015-208659 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2015-208659 C5099203!5099203 !26857698     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26857698 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Rheum+Dis 2016 ; 75 (11 ): 2029-2036 Nephropedia Template TP {{tp|p=26857698 |t=2016. Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren s syndrome reveals regulatory effects at interferon-induced genes |pdf=|usr=}}{{26857698 }} gab.com Text Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren s syndrome reveals regulatory effects at interferon-induced genes JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26857698 #FOAvip OBJECTIVES: Increasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study was to investigate the role of DNA methylation in pSS by analysing multiple tissues from patients and controls. METHODS: Genome-wide DNA methylation profiles were generated using HumanMethylation450K BeadChips for whole blood, CD19+ B cells and minor salivary gland biopsies. Gene expression was analysed in CD19+ B cells by RNA-sequencing. Analysis of genetic regulatory effects on DNA methylation at known pSS risk loci was performed. RESULTS: We identified prominent hypomethylation of interferon (IFN)-regulated genes in whole blood and CD19+ B cells, including at the genes MX1, IFI44L and PARP9, replicating previous reports in pSS, as well as identifying a large number of novel associations. Enrichment for genomic overlap with histone marks for enhancer and promoter regions was observed. We showed for the first time that hypomethylation of IFN-regulated genes in pSS B cells was associated with their increased expression. In minor salivary gland biopsies we observed hypomethylation of the IFN-induced gene OAS2. Pathway and disease analysis resulted in enrichment of antigen presentation, IFN signalling and lymphoproliferative disorders. Evidence for genetic control of methylation levels at known pSS risk loci was observed. CONCLUSIONS: Our study highlights the role of epigenetic regulation of IFN-induced genes in pSS where replication is needed for novel findings. The association with altered gene expression suggests a functional mechanism for differentially methylated CpG sites in pSS aetiology. Twit Text FOAVip Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren s syndrome reveals regulatory effects at interferon-induced genes ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26857698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26857698 #FOAvip English Wikipedia <ref>{{Cite pmid|26857698 }}</ref> Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren s syndrome reveals regulatory effects at interferon-induced genes #MMPMID26857698 Imgenberg-Kreuz J ; Sandling JK ; Almlöf JC ; Nordlund J ; Signér L ; Norheim KB ; Omdal R ; Rönnblom L ; Eloranta ML ; Syvänen AC ; Nordmark G Ann Rheum Dis 2016[Nov]; 75 (11 ): 2029-2036 PMID26857698 show ga OBJECTIVES: Increasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study was to investigate the role of DNA methylation in pSS by analysing multiple tissues from patients and controls. METHODS: Genome-wide DNA methylation profiles were generated using HumanMethylation450K BeadChips for whole blood, CD19+ B cells and minor salivary gland biopsies. Gene expression was analysed in CD19+ B cells by RNA-sequencing. Analysis of genetic regulatory effects on DNA methylation at known pSS risk loci was performed. RESULTS: We identified prominent hypomethylation of interferon (IFN)-regulated genes in whole blood and CD19+ B cells, including at the genes MX1, IFI44L and PARP9, replicating previous reports in pSS, as well as identifying a large number of novel associations. Enrichment for genomic overlap with histone marks for enhancer and promoter regions was observed. We showed for the first time that hypomethylation of IFN-regulated genes in pSS B cells was associated with their increased expression. In minor salivary gland biopsies we observed hypomethylation of the IFN-induced gene OAS2. Pathway and disease analysis resulted in enrichment of antigen presentation, IFN signalling and lymphoproliferative disorders. Evidence for genetic control of methylation levels at known pSS risk loci was observed. CONCLUSIONS: Our study highlights the role of epigenetic regulation of IFN-induced genes in pSS where replication is needed for novel findings. The association with altered gene expression suggests a functional mechanism for differentially methylated CpG sites in pSS aetiology. |*DNA Methylation [MESH] |*Epigenesis, Genetic [MESH] |2',5'-Oligoadenylate Synthetase/genetics [MESH] |Adult [MESH] |Aged [MESH] |Antigens, CD19/genetics [MESH] |Antigens/genetics [MESH] |Case-Control Studies [MESH] |Cytoskeletal Proteins/genetics [MESH] |Female [MESH] |Gene Expression [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH] |Interferons/*genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Myxovirus Resistance Proteins/genetics [MESH] |Neoplasm Proteins/genetics [MESH] |Poly(ADP-ribose) Polymerases/genetics [MESH] |Salivary Glands, Minor/pathology [MESH]Genome-wide DNA methylation analysis in multiple tissues in primary Sj(epmc).pdf DeepDyve Pubget Overpricing