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10.1136/gutjnl-2015-310142 http://scihub22266oqcxt.onion/10.1136/gutjnl-2015-310142 C5099199!5099199 !26338825     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26338825 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gut 2016 ; 65 (11 ): 1784-1792 Nephropedia Template TP {{tp|p=26338825 |t=2016. Sequential therapy for 10?days versus triple therapy for 14?days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial |pdf=|usr=}}{{26338825 }} gab.com Text Sequential therapy for 10 days versus triple therapy for 14 days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial JO: Gut http://www.kidney.de/pget.php?&tw=1&pmid=26338825 #FOAvip OBJECTIVE: Significant heterogeneity was observed in previous trials that assessed the efficacies of sequential therapy for 10?days (S10) versus triple therapy for 14?days (T14) in the first-line treatment of Helicobacter pylori. We aimed to compare the efficacy of S10 and T14 and assess the factors affecting their efficacies. DESIGN: We conducted this open-label randomised multicentre trial in eight hospitals and one community in Taiwan. 1300 adult subjects with H pylori infection naïve to treatment were randomised (1:1) to receive S10 (lansoprazole and amoxicillin for the first 5?days, followed by lansoprazole, clarithromycin and metronidazole for another 5?days) or T14 (lansoprazole, amoxicillin and clarithromycin for 14?days). All drugs were given twice daily. Successful eradication was defined as negative (13)C-urea breath test at least 6?weeks after treatment. Our primary outcome was the eradication rate by intention-to-treat (ITT) and per-protocol (PP) analyses. Antibiotic resistance was determined by agar dilution test. RESULTS: The eradication rates of S10 and T14 were 87.2% (567/650, 95% CI 84.4% to 89.6%) and 85.7% (557/650, 95% CI 82.8% to 88.2%) in the ITT analysis, respectively, and were 91.6% (556/607, 95% CI 89.1% to 93.4%) and 91.0% (548/602, 95% CI 88.5% to 93.1%) in the PP analysis, respectively. There were no differences in compliance or adverse effects. The eradication rates in strains susceptible and resistant to clarithromycin were 90.7% and 62.2%, respectively, for S10, and were 91.5% and 44.4%, respectively, for T14. The efficacy of T14, but not S10, was affected by CYP2C19 polymorphism. CONCLUSIONS: S10 was not superior to T14 in areas with low clarithromycin resistance. TRIAL REGISTRATION NUMBER: NCT01607918. Twit Text FOAVip Sequential therapy for 10 days versus triple therapy for 14 days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial ????Gut http://www.kidney.de/pget.php?&tw=1&pmid=26338825 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26338825 #FOAvip English Wikipedia <ref>{{Cite pmid|26338825 }}</ref> Sequential therapy for 10?days versus triple therapy for 14?days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial #MMPMID26338825 Liou JM ; Chen CC ; Chang CY ; Chen MJ ; Chen CC ; Fang YJ ; Lee JY ; Yang TH ; Luo JC ; Wu JY ; Liou TC ; Chang WH ; Hsu YC ; Tseng CH ; Chang CC ; Bair MJ ; Liu TY ; Hsieh CF ; Tsao FY ; Shun CT ; Lin JT ; Lee YC ; Wu MS Gut 2016[Nov]; 65 (11 ): 1784-1792 PMID26338825 show ga OBJECTIVE: Significant heterogeneity was observed in previous trials that assessed the efficacies of sequential therapy for 10?days (S10) versus triple therapy for 14?days (T14) in the first-line treatment of Helicobacter pylori. We aimed to compare the efficacy of S10 and T14 and assess the factors affecting their efficacies. DESIGN: We conducted this open-label randomised multicentre trial in eight hospitals and one community in Taiwan. 1300 adult subjects with H pylori infection naïve to treatment were randomised (1:1) to receive S10 (lansoprazole and amoxicillin for the first 5?days, followed by lansoprazole, clarithromycin and metronidazole for another 5?days) or T14 (lansoprazole, amoxicillin and clarithromycin for 14?days). All drugs were given twice daily. Successful eradication was defined as negative (13)C-urea breath test at least 6?weeks after treatment. Our primary outcome was the eradication rate by intention-to-treat (ITT) and per-protocol (PP) analyses. Antibiotic resistance was determined by agar dilution test. RESULTS: The eradication rates of S10 and T14 were 87.2% (567/650, 95% CI 84.4% to 89.6%) and 85.7% (557/650, 95% CI 82.8% to 88.2%) in the ITT analysis, respectively, and were 91.6% (556/607, 95% CI 89.1% to 93.4%) and 91.0% (548/602, 95% CI 88.5% to 93.1%) in the PP analysis, respectively. There were no differences in compliance or adverse effects. The eradication rates in strains susceptible and resistant to clarithromycin were 90.7% and 62.2%, respectively, for S10, and were 91.5% and 44.4%, respectively, for T14. The efficacy of T14, but not S10, was affected by CYP2C19 polymorphism. CONCLUSIONS: S10 was not superior to T14 in areas with low clarithromycin resistance. TRIAL REGISTRATION NUMBER: NCT01607918. |*Amoxicillin/administration & dosage/adverse effects [MESH] |*Clarithromycin/administration & dosage/adverse effects [MESH] |*Helicobacter pylori/drug effects/isolation & purification [MESH] |*Lansoprazole/administration & dosage/adverse effects [MESH] |*Metronidazole/administration & dosage/adverse effects [MESH] |Adult [MESH] |Ambulatory Care/*statistics & numerical data [MESH] |Anti-Bacterial Agents/administration & dosage/adverse effects [MESH] |Breath Tests/methods [MESH] |Drug Administration Schedule [MESH] |Drug Monitoring/methods [MESH] |Drug Therapy, Combination/methods [MESH] |Female [MESH] |Helicobacter Infections/diagnosis/*drug therapy/microbiology [MESH] |Hospitalization/*statistics & numerical data [MESH] |Humans [MESH] |Male [MESH] |Proton Pump Inhibitors/administration & dosage/adverse effects [MESH]Sequential therapy for 10?days versus triple therapy for 14?days in th(epmc).pdf DeepDyve Pubget Overpricing