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10.1136/gutjnl-2015-311292 http://scihub22266oqcxt.onion/10.1136/gutjnl-2015-311292 C5099193!5099193!27624887     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gut 2016 ; 65 (11): 1895-905 Nephropedia Template TP {{tp|p=27624887|t=2016. Epigenetics in liver disease: from biology to therapeutics |pdf=|usr=}}{{27624887}} gab.com Text Epigenetics in liver disease: from biology to therapeutics JO: Gut http://www.kidney.de/pget.php?&tw=1&pmid=27624887 #FOAvip Knowledge of the fundamental epigenetic mechanisms governing gene expression and cellular phenotype are sufficiently advanced that novel insights into the epigenetic control of chronic liver disease are now emerging. Hepatologists are in the process of shedding light on the roles played by DNA methylation, histone/chromatin modifications and non-coding RNAs in specific liver pathologies. Alongside these discoveries are advances in the technologies for the detection and quantification of epigenetic biomarkers, either directly from patient tissue or from body fluids. The premise for this review is to survey the recent advances in the field of liver epigenetics and to explore their potential for translation by industry and clinical hepatologists for the design of novel therapeutics and diagnostic/prognostic biomarkers. In particular, we present findings in the context of hepatocellular carcinoma, fibrosis and non-alcoholic fatty liver disease, where there is urgent unmet need for new clinical interventions and biomarkers. Twit Text FOAVip Epigenetics in liver disease: from biology to therapeutics ????Gut http://www.kidney.de/pget.php?&tw=1&pmid=27624887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27624887 #FOAvip English Wikipedia <ref>{{Cite pmid|27624887}}</ref> Epigenetics in liver disease: from biology to therapeutics #MMPMID27624887 Hardy T; Mann DA Gut 2016[Nov]; 65 (11): 1895-905 PMID27624887show ga Knowledge of the fundamental epigenetic mechanisms governing gene expression and cellular phenotype are sufficiently advanced that novel insights into the epigenetic control of chronic liver disease are now emerging. Hepatologists are in the process of shedding light on the roles played by DNA methylation, histone/chromatin modifications and non-coding RNAs in specific liver pathologies. Alongside these discoveries are advances in the technologies for the detection and quantification of epigenetic biomarkers, either directly from patient tissue or from body fluids. The premise for this review is to survey the recent advances in the field of liver epigenetics and to explore their potential for translation by industry and clinical hepatologists for the design of novel therapeutics and diagnostic/prognostic biomarkers. In particular, we present findings in the context of hepatocellular carcinoma, fibrosis and non-alcoholic fatty liver disease, where there is urgent unmet need for new clinical interventions and biomarkers. äEpigenetics in liver disease: from biology to therapeutics (epmc).pdf DeepDyve Pubget Overpricing