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10.3389/fphar.2016.00422 http://scihub22266oqcxt.onion/10.3389/fphar.2016.00422 C5099166!5099166!27877130     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27877130&cmd=llinks): Failed to open stream: HTTP request failed! 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Cannabidiol as a Potential New Type of an Antipsychotic A Critical Review of the Evidence |pdf=|usr=}}{{27877130}} gab.com Text Cannabidiol as a Potential New Type of an Antipsychotic A Critical Review of the Evidence JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27877130 #FOAvip There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the development of schizophrenia, triggered by the phytocannabinoid delta-9-tetrahydrocannabinol (?9-THC), cannabidiol, the second most important phytocannabinoid, appears to have no psychotomimetic potential. Although, results from animal studies are inconsistent to a certain extent and seem to depend on behavioral paradigms, treatment duration and experimental conditions applied, cannabidiol has shown antipsychotic properties in both rodents and rhesus monkeys. After some individual treatment attempts, the first randomized, double-blind controlled clinical trial demonstrated that in acute schizophrenia cannabidiol exerts antipsychotic properties comparable to the antipsychotic drug amisulpride while being accompanied by a superior, placebo-like side effect profile. As the clinical improvement by cannabidiol was significantly associated with elevated anandamide levels, it appears likely that its antipsychotic action is based on mechanisms associated with increased anandamide concentrations. Although, a plethora of mechanisms of action has been suggested, their potential relevance for the antipsychotic effects of cannabidiol still needs to be investigated. The clarification of these mechanisms as well as the establishment of cannabidiol?s antipsychotic efficacy and its hopefully benign side-effect profile remains the subject of a number of previously started clinical trials. Twit Text FOAVip Cannabidiol as a Potential New Type of an Antipsychotic A Critical Review of the Evidence ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27877130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27877130 #FOAvip English Wikipedia <ref>{{Cite pmid|27877130}}</ref> Cannabidiol as a Potential New Type of an Antipsychotic A Critical Review of the Evidence #MMPMID27877130 Rohleder C; Müller JK; Lange B; Leweke FM Front Pharmacol 2016[]; 7 (ä): ä PMID27877130show ga There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the development of schizophrenia, triggered by the phytocannabinoid delta-9-tetrahydrocannabinol (?9-THC), cannabidiol, the second most important phytocannabinoid, appears to have no psychotomimetic potential. Although, results from animal studies are inconsistent to a certain extent and seem to depend on behavioral paradigms, treatment duration and experimental conditions applied, cannabidiol has shown antipsychotic properties in both rodents and rhesus monkeys. After some individual treatment attempts, the first randomized, double-blind controlled clinical trial demonstrated that in acute schizophrenia cannabidiol exerts antipsychotic properties comparable to the antipsychotic drug amisulpride while being accompanied by a superior, placebo-like side effect profile. As the clinical improvement by cannabidiol was significantly associated with elevated anandamide levels, it appears likely that its antipsychotic action is based on mechanisms associated with increased anandamide concentrations. Although, a plethora of mechanisms of action has been suggested, their potential relevance for the antipsychotic effects of cannabidiol still needs to be investigated. The clarification of these mechanisms as well as the establishment of cannabidiol?s antipsychotic efficacy and its hopefully benign side-effect profile remains the subject of a number of previously started clinical trials. äCannabidiol as a Potential New Type of an Antipsychotic A Critical Re(epmc).pdf DeepDyve Pubget Overpricing