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10.3389/fphar.2016.00419

http://scihub22266oqcxt.onion/10.3389/fphar.2016.00419
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C5099146!5099146!27877129
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suck abstract from ncbi


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pmid27877129      Front+Pharmacol 2016 ; 7 (ä): ä
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  • Curcumin Inhibits Transforming Growth Factor ? Induced Differentiation of Mouse Lung Fibroblasts to Myofibroblasts #MMPMID27877129
  • Liu D; Gong L; Zhu H; Pu S; Wu Y; Zhang W; Huang G
  • Front Pharmacol 2016[]; 7 (ä): ä PMID27877129show ga
  • Transforming growth factor ? (TGF-?) induced differentiation of lung fibroblasts to myofibroblasts is a key event in the pathogenesis of pulmonary fibrosis. This study aimed to evaluate the effect of curcumin on TGF-? induced differentiation of lung fibroblasts to myofibroblasts and explore the underlying mechanism. Mouse lung fibroblasts were cultured and treated with TGF-?2 and curcumin or rosiglitazone. Cell vitality was examined by MTT assay. The secretion of collagen-1 was assessed by ELISA. ? smooth muscle actin (?-SMA) was visualized by immunofluorescence technique. The expression of peroxisome proliferator activated receptor ? (PPAR-?) and platelet derived growth factor R ? (PDGFR-?) was detected by PCR and Western blot analysis. We found that curcumin and rosiglitazone inhibited the proliferation and TGF-? induced differentiation of mouse lung fibroblasts. In addition, curcumin and rosiglitazone inhibited collagen-1 secretion and ?-SMA expression in mouse lung fibroblasts. Furthermore, curcumin and rosiglitazone upregulated PPAR-? and downregulated PDGFR-? expression in mouse lung fibroblasts. In conclusion, our study reveals novel mechanism by which curcumin inhibits TGF-?2 driven differentiation of lung fibroblasts to myofibroblasts. Curcumin could potentially be used for effective treatment of pulmonary fibrosis.
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