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10.1016/j.prostaglandins.2016.08.001 http://scihub22266oqcxt.onion/10.1016/j.prostaglandins.2016.08.001 C5099119!5099119!27554058     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prostaglandins+Other+Lipid+Mediat 2016 ; 126 (ä): 1-8 Nephropedia Template TP {{tp|p=27554058|t=2016. Cytosolic phospholipase A2? increases proliferation and de-differentiation of human renal tubular epithelial cells |pdf=|usr=}}{{27554058}} gab.com Text Cytosolic phospholipase A2 increases proliferation and de-differentiation of human renal tubular epithelial cells JO: Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=27554058 #FOAvip The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2?) enzyme controls the release of arachidonic acid from membrane bound phospholipids and is the rate-limiting step in production of eicosanoids. A variety of different kidney injuries activate cPLA2?, therefore we hypothesized that cPLA2? activity would regulate pathologic processes in HK-2 cells, a human renal tubular epithelial cell line, by regulating cell phenotype and proliferation. In two lentiviral cPLA2?-silenced knockdowns, we observed decreased proliferation and increased apoptosis compared to control HK-2 cells. cPLA2?-silenced cells also demonstrated an altered morphology, had increased expression E-cadherin, and decreased expression of Ncadherin. Increased levels of E-cadherin were associated with increased promoter activity and decreased levels of SNAIL1, SNAIL2, and ZEB1, transcriptional repressors of E-cadherin expression. Addition of exogenous arachidonic acid, but not PGE2, reversed the phenotypic changes in cPLA2?-silenced cells. These data suggest that cPLA2? may play a key role in renal repair after injury through a PGE2-independent mechanism. Twit Text FOAVip Cytosolic phospholipase A2 increases proliferation and de-differentiation of human renal tubular epithelial cells ????Prostaglandins Other Lipid Mediat http://www.kidney.de/pget.php?&tw=1&pmid=27554058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27554058 #FOAvip English Wikipedia <ref>{{Cite pmid|27554058}}</ref> Cytosolic phospholipase A2? increases proliferation and de-differentiation of human renal tubular epithelial cells #MMPMID27554058 Montford JR; Lehman AM; Scobey MS; Weiser-Evans MC; Nemenoff RA; Furgeson SB Prostaglandins Other Lipid Mediat 2016[Nov]; 126 (ä): 1-8 PMID27554058show ga The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2?) enzyme controls the release of arachidonic acid from membrane bound phospholipids and is the rate-limiting step in production of eicosanoids. A variety of different kidney injuries activate cPLA2?, therefore we hypothesized that cPLA2? activity would regulate pathologic processes in HK-2 cells, a human renal tubular epithelial cell line, by regulating cell phenotype and proliferation. In two lentiviral cPLA2?-silenced knockdowns, we observed decreased proliferation and increased apoptosis compared to control HK-2 cells. cPLA2?-silenced cells also demonstrated an altered morphology, had increased expression E-cadherin, and decreased expression of Ncadherin. Increased levels of E-cadherin were associated with increased promoter activity and decreased levels of SNAIL1, SNAIL2, and ZEB1, transcriptional repressors of E-cadherin expression. Addition of exogenous arachidonic acid, but not PGE2, reversed the phenotypic changes in cPLA2?-silenced cells. These data suggest that cPLA2? may play a key role in renal repair after injury through a PGE2-independent mechanism. äCytosolic phospholipase A2? increases proliferation and de-differentia(epmc).pdf DeepDyve Pubget Overpricing