Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.2147/OPTH.S120197 http://scihub22266oqcxt.onion/10.2147/OPTH.S120197 C5098596!5098596!27843288     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Ophthalmol 2016 ; 10 (ä): 2187-90 Nephropedia Template TP {{tp|p=27843288|t=2016. Leber?s hereditary optic neuropathy is multiorgan not mono-organ |pdf=|usr=}}{{27843288}} gab.com Text Leber s hereditary optic neuropathy is multiorgan not mono-organ JO: Clin Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=27843288 #FOAvip Leber?s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder with bilateral loss of central vision primarily due to mitochondrial DNA (mtDNA) mutations in subunits of complex I in the respiratory chain (primary LHON mutations), while other mtDNA mutations can also be causative. Since the first description, it is known that LHON is not restricted to the eyes but is a multisystem disorder additionally involving the central nervous system, ears, endocrinological organs, heart, bone marrow, arteries, kidneys, or the peripheral nervous system. Multisystem involvement may start before or after the onset of visual impairment. Involvement of organs other than the eyes may be subclinical depending on age, ethnicity, and possibly the heteroplasmy rate of the responsible primary LHON mutation. Primary LHON mutations may rarely manifest without ocular compromise but with arterial hypertension, various neurodegenerative diseases, or Leigh syndrome. Patients with LHON need to be closely followed up to detect at which point organs other than the eyes become affected. Multiorgan disease in LHON often responds more favorably to symptomatic treatment than the ocular compromise. Twit Text FOAVip Leber s hereditary optic neuropathy is multiorgan not mono-organ ????Clin Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=27843288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27843288 #FOAvip English Wikipedia <ref>{{Cite pmid|27843288}}</ref> Leber?s hereditary optic neuropathy is multiorgan not mono-organ #MMPMID27843288 Finsterer J; Zarrouk-Mahjoub S Clin Ophthalmol 2016[]; 10 (ä): 2187-90 PMID27843288show ga Leber?s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder with bilateral loss of central vision primarily due to mitochondrial DNA (mtDNA) mutations in subunits of complex I in the respiratory chain (primary LHON mutations), while other mtDNA mutations can also be causative. Since the first description, it is known that LHON is not restricted to the eyes but is a multisystem disorder additionally involving the central nervous system, ears, endocrinological organs, heart, bone marrow, arteries, kidneys, or the peripheral nervous system. Multisystem involvement may start before or after the onset of visual impairment. Involvement of organs other than the eyes may be subclinical depending on age, ethnicity, and possibly the heteroplasmy rate of the responsible primary LHON mutation. Primary LHON mutations may rarely manifest without ocular compromise but with arterial hypertension, various neurodegenerative diseases, or Leigh syndrome. Patients with LHON need to be closely followed up to detect at which point organs other than the eyes become affected. Multiorgan disease in LHON often responds more favorably to symptomatic treatment than the ocular compromise. äLeber?s hereditary optic neuropathy is multiorgan not mono-organ (epmc).pdf DeepDyve Pubget Overpricing