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10.14797/mdcj-12-3-146

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suck abstract from ncbi


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pmid27826368
      Methodist+Debakey+Cardiovasc+J 2016 ; 12 (3 ): 146-150
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  • Native and Reconstituted Plasma Lipoproteins in Nanomedicine: Physicochemical Determinants of Nanoparticle Structure, Stability, and Metabolism #MMPMID27826368
  • Pownall HJ ; Rosales C ; Gillard BK ; Ferrari M
  • Methodist Debakey Cardiovasc J 2016[Sep]; 12 (3 ): 146-150 PMID27826368 show ga
  • Although many acute and chronic diseases are managed via pharmacological means, challenges remain regarding appropriate drug targeting and maintenance of therapeutic levels within target tissues. Advances in nanotechnology will overcome these challenges through the development of lipidic particles, including liposomes, lipoproteins, and reconstituted high-density lipoproteins (rHDL) that are potential carriers of water-soluble, hydrophobic, and amphiphilic molecules. Herein we summarize the properties of human plasma lipoproteins and rHDL, identify the physicochemical determinants of lipid transfer between phospholipid surfaces, and discuss strategies for increasing the plasma half-life of lipoprotein- and liposome-associated molecules.
  • |*Nanoparticles [MESH]
  • |Drug Delivery Systems/*methods [MESH]
  • |Humans [MESH]
  • |Lipoproteins/*blood [MESH]
  • |Liposomes [MESH]
  • |Nanomedicine/*methods [MESH]


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