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2016 ; 12
(3
): 146-150
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Native and Reconstituted Plasma Lipoproteins in Nanomedicine: Physicochemical
Determinants of Nanoparticle Structure, Stability, and Metabolism
#MMPMID27826368
Pownall HJ
; Rosales C
; Gillard BK
; Ferrari M
Methodist Debakey Cardiovasc J
2016[Sep]; 12
(3
): 146-150
PMID27826368
show ga
Although many acute and chronic diseases are managed via pharmacological means,
challenges remain regarding appropriate drug targeting and maintenance of
therapeutic levels within target tissues. Advances in nanotechnology will
overcome these challenges through the development of lipidic particles, including
liposomes, lipoproteins, and reconstituted high-density lipoproteins (rHDL) that
are potential carriers of water-soluble, hydrophobic, and amphiphilic molecules.
Herein we summarize the properties of human plasma lipoproteins and rHDL,
identify the physicochemical determinants of lipid transfer between phospholipid
surfaces, and discuss strategies for increasing the plasma half-life of
lipoprotein- and liposome-associated molecules.