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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Biotechnol 2016 ; 39 (ä): 182-91 Nephropedia Template TP
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RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs #MMPMID27132125
Strobel EJ; Watters KE; Loughrey D; Lucks JB
Curr Opin Biotechnol 2016[Jun]; 39 (ä): 182-91 PMID27132125show ga
RNAs assume sophisticated structures that are active in myriad cellular processes. In this review, we highlight newly identified ribozymes, riboswitches and small RNAs, some of which control the function of cellular metabolic and gene expression networks. We then examine recent developments in genome-wide RNA structure probing technologies that are yielding new insights into the structural landscape of the transcriptome. Finally, we discuss how these RNA ?structomic? methods can address emerging questions in RNA systems biology, from the mechanisms behind long non-coding RNAs to new bases for human diseases.