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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Biotechnol
2016 ; 39
(ä): 182-191
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RNA systems biology: uniting functional discoveries and structural tools to
understand global roles of RNAs
#MMPMID27132125
Strobel EJ
; Watters KE
; Loughrey D
; Lucks JB
Curr Opin Biotechnol
2016[Jun]; 39
(ä): 182-191
PMID27132125
show ga
RNAs assume sophisticated structures that are active in myriad cellular
processes. In this review, we highlight newly identified ribozymes, riboswitches,
and small RNAs, some of which control the function of cellular metabolic and gene
expression networks. We then examine recent developments in genome-wide RNA
structure probing technologies that are yielding new insights into the structural
landscape of the transcriptome. Finally, we discuss how these RNA 'structomic'
methods can address emerging questions in RNA systems biology, from the
mechanisms behind long non-coding RNAs to new bases for human diseases.