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10.1038/srep36315 http://scihub22266oqcxt.onion/10.1038/srep36315 C5098240!5098240 !27819323     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27819323 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 36315 Nephropedia Template TP {{tp|p=27819323 |t=2016. Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation |pdf=|usr=}}{{27819323 }} gab.com Text Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27819323 #FOAvip NLRP3 (NOD-like receptor family, pyrin domain containing 3) is a member of the inflammasome family and is of special interest in renal disease. Experimental studies have shown that Nlrp3 plays a significant role in the induction of renal damage and dysfunction in acute and chronic renal injury. However, the role of NLRP3 in human renal disease is completely unknown. From a retrospective cohort study, we determined in 1271 matching donor and recipient samples if several NLRP3 single nucelotide polymorphisms (SNPs) were associated with primary non-function (PNF), delayed graft function (DGF), biopsy-proven acute rejection (BPAR) and death-censored graft and patient survival. NLRP3 gain-of-function SNP (rs35829419) in donors was associated with an increased risk of BPAR while NLRP3 loss-of-function SNP (rs6672995) in the recipient was associated with a decreased risk of BPAR in the first year following renal transplantation (HR 1.91, 95% CI 1.38-2.64, P?<?0.001 and HR 0.73, 95% CI 0.55-0.97, P?=?0.03 resp.). NLRP3 SNPs in both donor and recipient were not associated with PNF, DGF, graft survival or patient survival. We conclude that genetic variants in the NLRP3 gene affect the risk of acute rejection following kidney transplantation. Twit Text FOAVip Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27819323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27819323 #FOAvip English Wikipedia <ref>{{Cite pmid|27819323 }}</ref> Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation #MMPMID27819323 Dessing MC ; Kers J ; Damman J ; Navis GJ ; Florquin S ; Leemans JC Sci Rep 2016[Nov]; 6 (ä): 36315 PMID27819323 show ga NLRP3 (NOD-like receptor family, pyrin domain containing 3) is a member of the inflammasome family and is of special interest in renal disease. Experimental studies have shown that Nlrp3 plays a significant role in the induction of renal damage and dysfunction in acute and chronic renal injury. However, the role of NLRP3 in human renal disease is completely unknown. From a retrospective cohort study, we determined in 1271 matching donor and recipient samples if several NLRP3 single nucelotide polymorphisms (SNPs) were associated with primary non-function (PNF), delayed graft function (DGF), biopsy-proven acute rejection (BPAR) and death-censored graft and patient survival. NLRP3 gain-of-function SNP (rs35829419) in donors was associated with an increased risk of BPAR while NLRP3 loss-of-function SNP (rs6672995) in the recipient was associated with a decreased risk of BPAR in the first year following renal transplantation (HR 1.91, 95% CI 1.38-2.64, P? |*Polymorphism, Single Nucleotide [MESH] |Adult [MESH] |Biopsy [MESH] |Delayed Graft Function [MESH] |Female [MESH] |Graft Rejection/*genetics/pathology [MESH] |Humans [MESH] |Kidney Diseases/genetics/*therapy [MESH] |Kidney Transplantation [MESH] |Male [MESH] |Middle Aged [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*genetics [MESH] |Retrospective Studies [MESH]Donor and recipient genetic variants in NLRP3 associate with early acu(epmc).pdf DeepDyve Pubget Overpricing